{"ok":true,"nota":{"id":"fc5243354cef0b7d","slug":"en-pacientes-con-sepsis-los-cambios-en-una-molecula-de-la-sangre-en-lo-fc5243","titulo":"En pacientes con sepsis, los cambios en una molécula de la sangre en los primeros días anticipan quién tiene m","resumen":"Investigadores de un hospital de Taiwán siguieron a adultos con sepsis atendidos en guardia entre 2022 y 2024. Midieron la molécula S1P en la sangre el primer día, al tercero y antes del alta o la muerte, y la compararon con la mortalidad a 60 días.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Tran, B. V., Chen, C.-L., Nguyen, T. N., Lin, Y.-C., Hu, K.-C., Hsu, C.-W., Hsu, S.-C.","url":"https://www.medrxiv.org/content/10.64898/2026.11.03.26367220v1?rss=1","imagen":"/hoy/portada/fc5243354cef0b7d","tema":"salud","subtemas":["sepsis","biomarcadores","guardia","mortalidad","terapia intensiva"],"entidades":["Hospital Wan Fang","Taiwán","Taipéi"],"formato":"dato","entretenimiento":false,"pubTs":"2026-11-05T00:00:00.000Z","indexTs":"2026-11-05T18:45:33.797Z","hash":"f5aeb8a8bb73de17d0c9fce2773d517b1587ef8144f0a054cf3871e2c1eff4af","tsa":{"time":"Nov  5 18:45:49 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"La sepsis puede empeorar en horas, y saber cuál paciente está en peligro es lo que más cuesta en una guardia. Este trabajo sugiere que no alcanza con un solo valor de laboratorio: importa cómo cambia la molécula con el tiempo. Si se confirma, podría servir como alerta temprana para decidir a quién internar en terapia intensiva. Por ahora es un estudio con un solo hospital y pocos pacientes, así que todavía no se puede usar en la práctica.","quienFirma":"Hospital Wan Fang, Taipéi (Taiwán)","confianza":"preprint","consulta":null},"sello":{"hash":"f5aeb8a8bb73de17d0c9fce2773d517b1587ef8144f0a054cf3871e2c1eff4af","sello":"45e2f0385bd87480baed6b9114a4e3c188f27687ea2842dfb171c7d7e927bf99","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6615777,"aleatorio":"744a5c4b614a84b18008d439e7d616f4072d4716ddf1167be9bf8133bb1832ab","tiempo":"2026-11-05T18:45:30.000Z"},"nist":{"cadena":2,"pulso":2014822,"salida":"75F7A17BDFD2ADBF9BF8864AC0E328AFE865F129CAA41E80E48592996213B2B5DD677638383E9D2BF5E78425070685C9E414DC59AB6C6A091B0A878866701EA3","tiempo":"2026-11-05T18:44:00.000Z"},"noAntes":"2026-11-05T18:45:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Nov  5 18:45:49 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Dynamic changes in plasma sphingosine-1-phosphate concentrations and mortality in sepsis: a prospective cohort study in the emergency department","descripcion":"Background Sepsis is a dynamic process with evolving host responses, biomarker changes, and organ dysfunction. Sphingosine-1-phosphate (S1P) is a bioactive lipid involved in endothelial and immune regulation. However, the clinical relevance of dynamic S1P changes in sepsis remains unclear. This study aimed to assess their association with mortality. Methods We conducted a prospective cohort study of adults recruited from the emergency department of Wan Fang Hospital between April 2022 and October 2024. Plasma S1P was measured by ELISA on days 1, 3, and before discharge or death. The primary outcome was 60-day mortality. S1P trajectories were defined by baseline concentrations and longitudina","pubDate":"2026-11-05","url":"https://www.medrxiv.org/content/10.64898/2026.11.03.26367220v1?rss=1"},"indexado":"2026-11-05T18:45:33.797Z"}}