{"ok":true,"nota":{"id":"f297eb74fd34550a","slug":"un-mecanismo-ligado-a-la-falta-de-oxigeno-aparece-vinculado-a-la-forma-f297eb","titulo":"Un mecanismo ligado a la falta de oxígeno aparece vinculado a la forma grave de COVID-19","resumen":"Un equipo internacional analizó datos de miles de pacientes hospitalizados y de muestras de sangre y células para estudiar si una proteína que responde a la falta de oxígeno se relaciona con los casos graves de COVID-19.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Zivanovic, M. N., Rakovic, I., Miric, A., Milosavljevic, M. Z., Milivojevic Dimitrijevic, N., Filipovic, N., Kosaric, J.","url":"https://www.medrxiv.org/content/10.64898/2026.10.23.26366304v1?rss=1","imagen":"/hoy/portada/f297eb74fd34550a","tema":"ciencia","subtemas":["covid-19","inflamación","oxígeno","biomarcadores","respuesta inmune"],"entidades":["México","Brasil","Serbia","Sao Paulo","Kragujevac"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-26T00:00:00.000Z","indexTs":"2026-10-26T20:03:50.039Z","hash":"59622710089ff6f1a2f059c9992d0e406713a1d5db3205c53a06c10b20ae3903","tsa":{"time":"Oct 26 20:04:13 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Este trabajo es una señal de que la respuesta del cuerpo a la falta de oxígeno, y su vínculo con la inflamación, podría explicar por qué algunas personas empeoran tanto. Para alguien de acá, todavía no cambia ningún tratamiento, pero sí muestra que la gravedad de la enfermedad no es solo cuestión del virus. Es un resultado a validar en otros grupos antes de sacar conclusiones prácticas.","quienFirma":"Equipo internacional con cohortes de México, Brasil y Serbia","confianza":"preprint","consulta":null},"sello":{"hash":"59622710089ff6f1a2f059c9992d0e406713a1d5db3205c53a06c10b20ae3903","sello":"54c8691accf2344240d81f34e60ab10ad807f5b81338b75759449167e5367b6b","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6587133,"aleatorio":"dc324b08f0f2561bca711f2c376451dc2f1171a6b816a539d57904b5c4cb0056","tiempo":"2026-10-26T20:03:30.000Z"},"nist":{"cadena":2,"pulso":2000760,"salida":"94054E94B60B549ECC074DB2FF32049D9C63F7D049ACA947173CD97D409323329B9AC702822A4BD77D88E442608FFE9345A5A7931C7B12D80ED0D14122E7FBBC","tiempo":"2026-10-26T20:03:00.000Z"},"noAntes":"2026-10-26T20:03:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 26 20:04:13 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Multi-scale analysis of the HIF1A hypoxia-inflammation axis in severe COVID-19","descripcion":"Objective and design: To test whether the hypoxia-inducible factor 1-alpha (HIF1A) axis links transcriptional, cellular, biomarker and host-genetic features of severe COVID-19, in a retrospective multi-scale observational study of public cohorts and one hospital cohort. Material or subjects: 35,268 hospitalized patients (Mexican national registry); 1,100 samples from five bulk RNA-seq cohorts; 25,773 peripheral neutrophils from six individuals; 326 hospitalized patients (Sao Paulo, Brazil); 93 hospitalized patients (University Clinical Center Kragujevac, Serbia). Treatment: None. Methods: Within-cohort effect sizes for a 10-gene HIF1A panel; single-cell pathway scoring; logistic regression a","pubDate":"2026-10-26","url":"https://www.medrxiv.org/content/10.64898/2026.10.23.26366304v1?rss=1"},"indexado":"2026-10-26T20:03:50.039Z"}}