{"ok":true,"nota":{"id":"f13d93fa15d205ae","slug":"en-el-cerebro-vivo-cada-senal-libera-varias-particulas-a-la-vez-y-no-u-f13d93","titulo":"En el cerebro vivo, cada señal libera varias partículas a la vez y no una sola","resumen":"Usando imágenes de dos fotones en cerebros de animales despiertos, los investigadores observaron que la transmisión entre neuronas suele liberar varias vesículas por impulso. Esto ocurre en distintas capas de la corteza y aumenta la fiabilidad de la señal.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Patel, P., Higley, M.","url":"https://www.biorxiv.org/content/10.64898/2026.10.18.759916v1?rss=1","imagen":"/hoy/portada/f13d93fa15d205ae","tema":"ciencia","subtemas":["neurociencia","sinapsis","neurotransmisores","corteza cerebral","imagen cerebral"],"entidades":[],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T16:38:44.280Z","hash":"f25d9b22e383ff66e86fdfa79ed65a5714e34afa25deedc6b07d086bc7e87539","tsa":{"time":"Oct 22 16:39:29 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Durante décadas se creyó que cada impulso nervioso liberaba una sola vesícula de neurotransmisor, lo que simplificaba los modelos del cerebro. Si la liberación múltiple es la regla, cada conexión entre neuronas puede transmitir mucha más información de la que se suponía. Eso obliga a revisar cómo se interpreta el funcionamiento del sistema nervioso, incluso en enfermedades donde esas conexiones fallan.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"f25d9b22e383ff66e86fdfa79ed65a5714e34afa25deedc6b07d086bc7e87539","sello":"771cf5fc8a79b18aa3f7055248e97af6413250739f96338c73bc78177678cff8","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575204,"aleatorio":"ac0f4a6ce509202540c9641abb3a70f7f06eeb36f68a34e1bc3e430369a775da","tiempo":"2026-10-22T16:39:00.000Z"},"nist":{"cadena":2,"pulso":1994801,"salida":"123765DCC46130497358D1E6393BF76FC82D205E2F260DEF171C4887B733C1209F31A193DDD877AB50C2E9F79D0A125A26712AD900F817275AC0E40E5C1C39BC","tiempo":"2026-10-22T16:38:00.000Z"},"noAntes":"2026-10-22T16:39:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 16:39:29 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Multiquantal transmission supports dynamic synaptic strength in vivo","descripcion":"In the central nervous system, synaptic transmission occurs through the probabilistic release of neurotransmitter vesicles following presynaptic action potentials (AP). Traditional models posit a single vesicle release event per AP, though experimental evidence indicates multivesicular release (MVR) may occur under some circumstances, greatly expanding the dynamic range and information content at single synapses. However, the quantal nature of synaptic transmission in the intact, waking brain is largely unknown. Here, we used two-photon imaging of iGluSnFR4f-expressing cortical axons and found that MVR dominates synaptic transmission at both layer 4 and layer 2/3 synapses, enhancing reliabil","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.18.759916v1?rss=1"},"indexado":"2026-10-22T16:38:44.280Z"}}