{"ok":true,"nota":{"id":"ed7a6ea66bf34aeb","slug":"una-variante-genetica-vinculada-a-la-obesidad-hace-que-las-mujeres-que-ed7a6e","titulo":"Una variante genética vinculada a la obesidad hace que las mujeres quemen menos grasa y guarden más energía","resumen":"Científicos estudiaron una variante del gen PGC-1α asociada a obesidad y diabetes tipo 2. Usaron células humanas y ratones con tres genotipos, machos y hembras, sometidos a distintas dietas y ayuno. Compararon cómo cada grupo procesaba la energía.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Galipeau, M., Jouvet, N., Schoumacher, M., Courty, E., Vandenbeek, R., Gunes, A., Braud, M., Fourgeux, C., Poschmann, J.","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759626v1?rss=1","imagen":"/hoy/portada/ed7a6ea66bf34aeb","tema":"salud","subtemas":["obesidad","diabetes tipo 2","genetica","metabolismo","diferencias por sexo"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T21:54:18.823Z","hash":"09f50b52854d109c19d47cf419696374877a87b201dd1f729e71d8185900f1bb","tsa":{"time":"Oct 22 21:55:38 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"El estudio muestra que la misma variante genética puede afectar el metabolismo de forma distinta en mujeres y en varones. Eso sugiere que los consejos generales para bajar de peso no siempre funcionan igual para todos. Para quien lleva años peleando con la balanza, la genética podría explicar por qué ciertas dietas no le dan resultado. Los datos vienen de ratones y células, así que falta comprobarlo en personas.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"09f50b52854d109c19d47cf419696374877a87b201dd1f729e71d8185900f1bb","sello":"e1f5d6653c65ca294f98902611b9bff9ab3b16a2042908abcac15748e4eaebb8","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575837,"aleatorio":"63461f681b6ee92f4c36de6febc3c3c4fe7c3906de725dea83aeab9ec81b1467","tiempo":"2026-10-22T21:55:30.000Z"},"nist":null,"noAntes":"2026-10-22T21:55:30.000Z"},"verificacion":{"drand":true,"nist":null},"tsa":{"time":"Oct 22 21:55:38 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"The PGC-1α Gly482Ser rs8192678 SNP reprograms oxidative metabolism to favor energy storage in females","descripcion":"The Gly482Ser SNP (rs8192678) in the peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene has been associated with obesity, type 2 diabetes and other human metabolic diseases. In this study, we found that human iPSCs carrying a serine risk allele had reduced respiratory capacity, and individuals living with overweight or obesity homozygous for the serine allele (S/S) exhibited a preference for carbohydrate oxidation following a high-fat meal. Using a PGC-1Ser481Gly knock-in mouse model, we performed metabolic phenotyping of male and female mice carrying the three genotypes (G/G, S/G, S/S) under acute nutritional challenges (chow, fasting and high-fat high-suga","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759626v1?rss=1"},"indexado":"2026-10-22T21:54:18.823Z"}}