{"ok":true,"nota":{"id":"e69f47022726baf1","slug":"la-primaquina-podria-reducir-la-transmision-de-malaria-ademas-de-curar-e69f47","titulo":"La primaquina podría reducir la transmisión de malaria además de curar a los enfermos","resumen":"Investigadores usaron modelos a múltiples escalas para estimar cuánto reduce la transmisión de Plasmodium falciparum la primaquina, un fármaco que actúa sobre los gametocitos, la forma que pasa del humano al mosquito. Se basaron en datos de una campaña de administración masiva de medicamentos.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Sun, X., Simpson, J. A., McCaw, J., Cao, P.","url":"https://www.medrxiv.org/content/10.64898/2026.10.21.26366166v1?rss=1","imagen":"/hoy/portada/e69f47022726baf1","tema":"salud","subtemas":["malaria","primaquina","transmisión de enfermedades","campañas sanitarias","modelado matemático"],"entidades":["Plasmodium falciparum","OMS"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-24T00:00:00.000Z","indexTs":"2026-10-24T16:02:27.654Z","hash":"d3571e25c1f5bcdc71c3fb436a73b591604d1c24af80c830717ab617c3f0fe61","tsa":{"time":"Oct 24 16:02:52 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Cortar la transmisión es tan importante como curar a cada paciente, porque un mosquito infectado puede contagiar a toda una comunidad. Si la primaquina reduce ese paso, las campañas de salud en zonas con malaria podrían ser más efectivas con una dosis adicional. El estudio es una predicción basada en modelos y datos de campo de un único trabajo previo, así que no mide directamente el efecto en cada región. Aun así, sugiere que una herramienta vieja puede tener un uso más amplio del que se le daba.","quienFirma":"medRxiv (institución principal no indicada)","confianza":"preprint","consulta":null},"sello":{"hash":"d3571e25c1f5bcdc71c3fb436a73b591604d1c24af80c830717ab617c3f0fe61","sello":"c402a3aa24b450be0453dd6cb3f905d5503845a60f629ae96ae4a084bea8bde0","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6580891,"aleatorio":"fdee5f21e083e1d54a95ae59401cf83616db17eef82d80b6f17ce42d6c874cd5","tiempo":"2026-10-24T16:02:30.000Z"},"nist":{"cadena":2,"pulso":1997639,"salida":"FDB1C43A1122BF20736ABA3B66DA9E6FE315E52D2FD0B03607BDF433EC3615B24347D46B3E9B862660DCA2F8375D79D5B261024A3AF6F3A455DCD470BDCC923D","tiempo":"2026-10-24T16:02:00.000Z"},"noAntes":"2026-10-24T16:02:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 24 16:02:52 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Predicting the impact of primaquine on Plasmodium falciparum transmission using multiscale modelling","descripcion":"Primaquine is currently the only widely available antimalarial drug that targets mature emph{Plasmodium falciparum} gametocytes, the life stage in the human bloodstream that mediates transmission from humans to mosquitoes. The only study that provided large-scale field data suitable for examining the additional impact of the WHO-recommended dose of 0.25 mg/kg primaquine in an artemisinin-based combination therapy (ACT)-based mass drug administration (MDA) campaign was reported by Deng et al. (2018, Clinical Infectious Diseases). The study showed that both ACT alone and ACT plus primaquine substantially reduced average monthly malaria hospital rates and the prevalence of infection after the M","pubDate":"2026-10-24","url":"https://www.medrxiv.org/content/10.64898/2026.10.21.26366166v1?rss=1"},"indexado":"2026-10-24T16:02:27.654Z"}}