{"ok":true,"nota":{"id":"e2720b70321fc60a","slug":"personas-con-fenilcetonuria-tratada-muestran-mas-ansiedad-y-depresion--e2720b","titulo":"Personas con fenilcetonuria tratada muestran más ansiedad y depresión en su vida diaria","resumen":"Treinta adultos con fenilcetonuria tratada desde chicos y treinta sin la condición completaron evaluaciones cuatro veces al día por siete días en su celular. Compararon cómo fluctúan sus síntomas de ansiedad y depresión en situaciones reales.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Hayse, B. E., Lane, S. P., Singh, S., Sacharow, S., Goodlett, B. D., Christ, S. E.","url":"https://www.medrxiv.org/content/10.64898/2026.10.23.26366355v1?rss=1","imagen":"/hoy/portada/e2720b70321fc60a","tema":"salud","subtemas":["fenilcetonuria","salud mental","ansiedad","depresión","evaluación ecológica momentánea"],"entidades":["medRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-26T00:00:00.000Z","indexTs":"2026-10-26T15:25:50.345Z","hash":"2782a1b7e42ef9302ecbc98c70fdfacea1b9049a6333c2c9201059419a1202ee","tsa":{"time":"Oct 26 15:26:22 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Hasta ahora los resultados sobre ansiedad y depresión en esta condición eran contradictorios, en parte porque se basaban en recuerdos. Este estudio registra el malestar en el momento, en la vida cotidiana, y eso mejora la precisión. Para una familia con un integrante con fenilcetonuria, implica que el seguimiento emocional tiene que ser parte del tratamiento. La muestra es chica y el trabajo es un preprint, así que conviene leerlo como una señal inicial.","quienFirma":"medRxiv (preprint; investigación clínica sobre fenilcetonuria)","confianza":"preprint","consulta":null},"sello":{"hash":"2782a1b7e42ef9302ecbc98c70fdfacea1b9049a6333c2c9201059419a1202ee","sello":"2ba68ee887abd5b996faa344cf8574326ceed2e7e30052653eb0f8a8f50871aa","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6586578,"aleatorio":"c7eacd3bdd6186c021eec2332dc0801458c4d48bb0315723a1f4715b256cc5fc","tiempo":"2026-10-26T15:26:00.000Z"},"nist":{"cadena":2,"pulso":2000482,"salida":"7CB5612A975B096AD2025D6029FC76EF2453D78476A5A81FDDF7BA6810BB1F95736BAA8A9C954033F423191BA434921471D2704F34765066B98EDFB41E21B8A2","tiempo":"2026-10-26T15:25:00.000Z"},"noAntes":"2026-10-26T15:26:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 26 15:26:22 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Ecological momentary assessment of anxiety and depression in individuals with early-treated phenylketonuria","descripcion":"Background. In addition to cognitive difficulties, individuals with early-treated phenylketonuria (PKU) may be at increased risk for anxiety and depression. However, previous findings are mixed, potentially due to reliance on retrospective self-report measures that are vulnerable to recall bias and lose resolution of day-to-day symptom fluctuations. The present study used ecological momentary assessment (EMA) to evaluate anxiety and depressive symptoms in adults with PKU in real-world settings. Methods. A sample of 30 adults with early-treated PKU and a demographically-similar sample of 30 adults without PKU completed smartphone-based EMA assessments four times daily over seven consecutive d","pubDate":"2026-10-26","url":"https://www.medrxiv.org/content/10.64898/2026.10.23.26366355v1?rss=1"},"indexado":"2026-10-26T15:25:50.345Z"}}