{"ok":true,"nota":{"id":"e24557f764240e4d","slug":"crean-tumores-impresos-en-3d-para-probar-colorantes-que-guian-cirugias-e24557","titulo":"Crean tumores impresos en 3D para probar colorantes que guían cirugías","resumen":"Desarrollaron modelos de tumores impresos en 3D, con geometría y propiedades ópticas ajustables, para evaluar nanofluoróforos usados en cirugía guiada por fluorescencia. Los modelos reproducen tumores subcutáneos, epiteliales e intraperitoneales.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"De Leon, I., Harun, A., Srivastava, I.","url":"https://www.biorxiv.org/content/10.64898/2026.10.18.757485v1?rss=1","imagen":"/hoy/portada/e24557f764240e4d","tema":"salud","subtemas":["cirugia oncologica","bioimpresion 3d","fluorescencia","nanotecnologia","modelos preclinicos"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-23T06:48:38.804Z","hash":"53dc1d10f07bf35439ff1137c2f3156f618119319cea59b6e711812f373a1682","tsa":{"time":"Oct 23 06:48:59 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Hoy los colorantes que iluminan un tumor durante la operación se prueban sobre todo en ratones, con muchas variables que no se pueden controlar. Estos modelos impresos permiten comparar productos de forma repetible y en condiciones parecidas a las del quirófano. Para un paciente de acá, eso puede significar cirugías con mejor delimitación del tumor en el futuro. Es una herramienta de desarrollo, no un tratamiento disponible hoy.","quienFirma":"Preprint en bioRxiv (institución principal no identificada en el resumen)","confianza":"preprint","consulta":null},"sello":{"hash":"53dc1d10f07bf35439ff1137c2f3156f618119319cea59b6e711812f373a1682","sello":"b8320cf3672378503e4eee857ce43adac8a69b7117732d50e63c490b21b9ffb3","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6576903,"aleatorio":"8e583525a288ba13cde66d0d6539d282d867cec58f75a0217a855687a27f9649","tiempo":"2026-10-23T06:48:30.000Z"},"nist":{"cadena":2,"pulso":1995651,"salida":"AA82134D649B7B25F10D77FD67053808011261EF94B49E048C931DF7D357E824C95C66604E50CE6E37F934A39EE493177DEA66983586EA3E4667145C3C8919D6","tiempo":"2026-10-23T06:48:00.000Z"},"noAntes":"2026-10-23T06:48:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 23 06:48:59 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Anatomically Programmable and Optically Tunable 3D-Bioprinted Tumor-Mimicking Phantoms for Quantitative Nanofluorophore Benchmarking","descripcion":"Surgical resection remains a primary treatment for solid tumors, with fluorescence-guided surgery offering improved intraoperative visualization and precision. However, conventional murine models provide limited control over anatomical and optical variables critical to evaluating fluorescent imaging agents. Here, we developed 3D-bioprinted, anatomically tailored and optically tunable tumor-mimicking phantoms (TMPs) as a reproducible platform for quantitative nanofluorophore evaluation under tissue-relevant surgical conditions. These TMPs recreate subcutaneous, epithelial, and intraperitoneal tumor presentations while enabling controlled variation of lesion geometry, spatial distribution, tis","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.18.757485v1?rss=1"},"indexado":"2026-10-23T06:48:38.804Z"}}