{"ok":true,"nota":{"id":"e1ccb06bb83dd837","slug":"una-molecula-del-propio-cuerpo-frena-a-las-celulas-que-sirven-de-refug-e1ccb0","titulo":"Una molécula del propio cuerpo frena a las células que sirven de refugio a la tuberculosis","resumen":"Investigadores estudiaron la esfingosina-1-fosfato, una molécula propia del organismo, en la tuberculosis multirresistente. Según el trabajo previo que citan, redujo la carga bacteriana, y este estudio analiza cómo influye en los macrófagos cargados de grasa donde la bacteria se esconde.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Kumar, A., Sharma, N., Singh, L. K., Hadda, V., Singh, A. K., Prakash, H.","url":"https://www.biorxiv.org/content/10.64898/2026.10.15.759318v1?rss=1","imagen":"/hoy/portada/e1ccb06bb83dd837","tema":"salud","subtemas":["tuberculosis","tuberculosis-multirresistente","macrofagos","esfingosina-1-fosfato","tratamiento"],"entidades":["Mycobacterium tuberculosis","S1P"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-20T00:00:00.000Z","indexTs":"2026-10-21T05:32:19.019Z","hash":"0e26384913cc212d0d19f8123dbec53cde7e04c2143c16046a51f0806fe43789","tsa":{"time":"Oct 21 05:32:48 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"La tuberculosis multirresistente es la que no responde a los antibióticos comunes, y las bacterias sobreviven escondidas dentro de macrófagos llenos de grasa. Si una molécula propia del cuerpo logra impedir que esas células se formen, se abre una vía de tratamiento distinta a los antibióticos. Para alguien de acá, donde la tuberculosis sigue presente, es una línea que vale seguir de cerca. Sin embargo, el estudio es preclínico, así que el efecto en humanos todavía no está probado.","quienFirma":"bioRxiv (preprint; institución principal no identificada en el extracto)","confianza":"preprint","consulta":null},"sello":{"hash":"0e26384913cc212d0d19f8123dbec53cde7e04c2143c16046a51f0806fe43789","sello":"4a7a733839bb2af62471877671090d577ee615b97d25505939413ce4b8adc96c","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6570990,"aleatorio":"197cfefbaae84a11019800f736fb3d999fc9deaffc98cec0c35453a67bb3b551","tiempo":"2026-10-21T05:32:00.000Z"},"nist":{"cadena":2,"pulso":1992700,"salida":"779B9C05152B4CBD1C0DC8A789A98414BB1FB7FC9BCD4C986DB35B0B6DFFACF69BCA3C8A248326F1AFCD58751A3730795B71A1BBC058A265C3BB6F3B3B74127C","tiempo":"2026-10-21T05:31:00.000Z"},"noAntes":"2026-10-21T05:32:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 21 05:32:48 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Sphingosine-1-Phosphate Restrains Foamy Macrophage Formation and Modulates Inflammation in Multidrug-Resistant Tuberculosis","descripcion":"The high abundance of lipid loaded foamy macrophages in the granulomatous lesions is a key hallmark of advanced pulmonary tuberculosis. These macrophages serve as lipid-rich intracellular hiding niches that provides Mycobacterium tuberculosis (M.tb) survival and persistence during prolonged anti-tubercular treatment. Persistent infection and dysregulated inflammatory responses further complicate disease control, particularly in multidrug-resistant tuberculosis (MDR-TB), highlighting the need for host-directed therapeutic strategies. Our previous preclinical study demonstrated the therapeutic potential of the host sphingolipid sphingosine-1-phosphate (S1P) in reducing the mycobacterial burden","pubDate":"2026-10-20","url":"https://www.biorxiv.org/content/10.64898/2026.10.15.759318v1?rss=1"},"indexado":"2026-10-21T05:32:19.019Z"}}