{"ok":true,"nota":{"id":"de889b72cfa59cf0","slug":"en-ratones-dos-zonas-del-cerebro-se-coordinan-para-anticipar-el-peligr-de889b","titulo":"En ratones, dos zonas del cerebro se coordinan para anticipar el peligro","resumen":"Investigadores registraron neuronas de ratones durante un entrenamiento de miedo. Encontraron que el cerebelo y el mesencéfalo activan neuronas en conjunto cuando aparece una señal que anticipa una amenaza.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Urrutia Desmaison, J. D., Lena, C., Popa, D.","url":"https://www.biorxiv.org/content/10.64898/2026.10.17.759883v1?rss=1","imagen":"/hoy/portada/de889b72cfa59cf0","tema":"ciencia","subtemas":["neurociencia","miedo","cerebelo","aprendizaje","ratones"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T10:38:41.125Z","hash":"ad6a50fda14eb2bf2df9233d2ca59b8ca0a6087511bbcf82cae000557bf5d2a6","tsa":{"time":"Oct 22 10:39:24 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"El aprendizaje del miedo es la base de muchas respuestas ante el peligro, y también de algunos trastornos de ansiedad. El estudio muestra que el cerebelo, que se suele asociar sólo con el equilibrio y el movimiento, participa en esa anticipación a través de conexiones con el mesencéfalo. Para una persona de acá, eso amplía el mapa de qué zonas intervienen en el miedo aprendido. Todavía se trabajó con ratones, y pasar esto a personas es un paso que falta dar.","quienFirma":"bioRxiv (preprint, sin revisión por pares)","confianza":"preprint","consulta":null},"sello":{"hash":"ad6a50fda14eb2bf2df9233d2ca59b8ca0a6087511bbcf82cae000557bf5d2a6","sello":"edd3f471109a79f820a3d65090b2feb9ace7e75c871fc01ca0b74c64a8c81f29","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6574484,"aleatorio":"17f8dc6691055e17d3340945fc697b1d14385d774dc400926b289d0664c160fb","tiempo":"2026-10-22T10:39:00.000Z"},"nist":{"cadena":2,"pulso":1994441,"salida":"917B00588BBAF41DD8C461E7D93EA47DC73C00983776285722380061C2505D68D1C49D178A1E9E1A422EEA35DB6367141AB79828DD0F9592CE1805F752B02469","tiempo":"2026-10-22T10:32:00.000Z"},"noAntes":"2026-10-22T10:39:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 10:39:24 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Coordinated cerebellar-midbrain activity for predictive signaling during fear learning in mice","descripcion":"Learning from experience to assess threat is crucial for survival and mental health. This function is known to involve several midbrain areas, notably the ventrolateral periaqueductal grey (vlPAG) and dorsal raphe nuclei (DRN). Recently it has been shown that fear learning involves projections from the cerebellar fastigial nucleus (FN) to the vlPAG. Here, we show using simultaneous single-unit recordings during fear conditioning that a subset of vlPAG/DRN and FN neurons acquire responses to conditioned cues following learning. Strikingly, these populations exhibit firing covariance and directional functional interactions consistent with their collaboration to the response to cues predicting ","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.17.759883v1?rss=1"},"indexado":"2026-10-22T10:38:41.125Z"}}