{"ok":true,"nota":{"id":"dafa8c36f1075965","slug":"las-herramientas-genomicas-fallan-al-detectar-resistencia-a-antibiotic-dafa8c","titulo":"Las herramientas genómicas fallan al detectar resistencia a antibióticos en mezclas de cepas de E. coli","resumen":"Investigadores simularon metagenomas de E. coli con distintas cepas mezcladas y evaluaron herramientas bioinformáticas para detectar genes de resistencia, virulencia y tipificación. Buscaban saber qué tan bien recuperan esa información de poblaciones heterogéneas.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Shridar, V. D., Engblom, S.","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.760091v1?rss=1","imagen":"/hoy/portada/dafa8c36f1075965","tema":"salud","subtemas":["resistencia antimicrobiana","e. coli","metagenomica","vigilancia sanitaria","bioinformatica"],"entidades":["Escherichia coli","bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-20T00:00:00.000Z","indexTs":"2026-10-20T12:15:39.527Z","hash":"e7122cc99e3b35d10dcb9ca6f8c80715c36178bf79fcddc4e207c9082f0407dd","tsa":{"time":"Oct 20 12:17:09 2026 GMT","provider":"freetsa.org"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Cuando los laboratorios de vigilancia secuencian muestras con varias cepas juntas, los programas que usan pueden pasar por alto genes de resistencia a antibióticos. Eso significa que un brote podría subestimarse justo en el momento en que más se necesita detectarlo. Para el sistema de salud argentino, la calidad de esta vigilancia depende de herramientas que todavía no siempre ven todo lo que hay.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"e7122cc99e3b35d10dcb9ca6f8c80715c36178bf79fcddc4e207c9082f0407dd","sello":null,"beacon":null,"verificacion":null,"tsa":{"time":"Oct 20 12:17:09 2026 GMT","provider":"freetsa.org"},"original":{"titulo":"The impact of strain heterogeneity on genomic profiling accuracy in mixed-strain Escherichia coli metagenomes","descripcion":"Metagenomic sequencing is increasingly used for surveillance of bacterial populations, enabling simultaneous characterisation of antimicrobial resistance, virulence, and epidemiologically relevant strain markers. However, the ability of commonly used bioinformatic tools to recover these features from heterogeneous populations remains incompletely understood. Here, we developed a controlled benchmarking framework based on simulated single-species Escherichia coli metagenomes generated from genomes with PCR-determined annotations. Assembly-based and read-based tools were evaluated for antimicrobial resistance gene (ARG) detection, virulence gene (VG) detection, multilocus sequence typing (MLST","pubDate":"2026-10-20","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.760091v1?rss=1"},"indexado":"2026-10-20T12:15:39.527Z"}}