{"ok":true,"nota":{"id":"d8a57f45f1da9726","slug":"una-prueba-simple-con-la-mano-mide-la-oxigenacion-del-musculo-y-distin-d8a57f","titulo":"Una prueba simple con la mano mide la oxigenación del músculo y distingue enfermedad mitocondrial de sarcopeni","resumen":"Investigadores compararon a 10 personas con enfermedad mitocondrial confirmada genéticamente con 19 controles. Usaron un ejercicio breve de apretar la mano y espectroscopía de infrarrojo cercano para medir cómo se oxigena el músculo durante el esfuerzo.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Devine, H., Brito da Silva, A., Hillman, S., Brownstein, C., Smith, S., Rao, K., Pickett, S., Turnbull, D., Whittaker, R","url":"https://www.medrxiv.org/content/10.64898/2026.10.21.26364901v1?rss=1","imagen":"/hoy/portada/d8a57f45f1da9726","tema":"salud","subtemas":["sarcopenia","enfermedad mitocondrial","envejecimiento","músculo","espectroscopía de infrarrojo cercano"],"entidades":[],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-22T04:37:56.220Z","hash":"58b2fd98059249c998effd53c860c247d0806afd3c8f29382807f657a71d8bed","tsa":{"time":"Oct 22 04:38:37 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"La pérdida de masa muscular con la edad, llamada sarcopenia, afecta la independencia de muchos adultos mayores argentinos y hoy cuesta medirla con precisión. Una prueba corta y no invasiva que detecte problemas de energía en el músculo podría ayudar a seguir la evolución de estos pacientes. Con apenas 10 casos de enfermedad mitocondrial, el resultado es preliminar.","quienFirma":"medRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"58b2fd98059249c998effd53c860c247d0806afd3c8f29382807f657a71d8bed","sello":"b480fed313afa86708e10865eef8fda8e7f268f4e573bb1387cbb565862e3244","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6573763,"aleatorio":"ac1ab9766ef209323093f9521e7402b29370fa8f04af200361451518fae9c9b2","tiempo":"2026-10-22T04:38:30.000Z"},"nist":{"cadena":2,"pulso":1994087,"salida":"2CAE0B0247F8B2C1365D5848B4971A88B86F8096596AB659C9B46851CC37B71B43230BE62392778D57CA4D0DAE3440419DC67D4E27A84A89E3AA5B314736F2A3","tiempo":"2026-10-22T04:38:00.000Z"},"noAntes":"2026-10-22T04:38:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 04:38:37 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Near infrared spectroscopy during non-ischaemic handgrip exercise reveals divergent muscle oxygenation signatures in mitochondrial disease and sarcopenia","descripcion":"Background: Mitochondrial dysfunction is a hallmark of ageing and is implicated in the pathogenesis of sarcopenia. Genetically confirmed mitochondrial disease provides a biologically definitive model of impaired oxidative phosphorylation against which novel functional assessments can be validated. We investigated whether a brief, submaximal, non-ischaemic intermittent isometric handgrip exercise protocol combined with Near Infra-Red Spectroscopy (NIRS) could detect distinct muscle oxygenation signatures in mitochondrial disease and sarcopenia. Methods: Adults with genetically confirmed mitochondrial disease (n=10, 7 female) and group-matched controls (n=19, 11 female), underwent assessment o","pubDate":"2026-10-21","url":"https://www.medrxiv.org/content/10.64898/2026.10.21.26364901v1?rss=1"},"indexado":"2026-10-22T04:37:56.220Z"}}