{"ok":true,"nota":{"id":"d723611ddeeddbfe","slug":"el-reflujo-acido-deja-una-huella-genetica-parecida-en-canceres-de-esof-d72361","titulo":"El reflujo ácido deja una huella genética parecida en cánceres de esófago en ocho países","resumen":"Analizaron 520 genomas completos de tumores de esófago y de la unión con el estómago en ocho países. Encontraron patrones de mutación muy similares, dominados por una firma vinculada al reflujo, y que la obesidad se asocia con esa firma en el esófago.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Torrens, L., Moody, S., Pang, J., Abedi-Ardekani, B., Zhang, H., Abbasi, A., Nunn, C., Fitzgerald, S., Gallego-Garcia, P","url":"https://www.medrxiv.org/content/10.64898/2026.10.21.26365720v1?rss=1","imagen":"/hoy/portada/d723611ddeeddbfe","tema":"salud","subtemas":["cáncer de esófago","reflujo gastroesofágico","obesidad","genómica del cáncer","prevención"],"entidades":["medRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-23T00:00:00.000Z","indexTs":"2026-10-23T18:12:31.737Z","hash":"40963003690e5d97cc4c9328c765007389f593c794e4a8154478870e6ac43451","tsa":{"time":"Oct 23 18:13:32 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Cerca de un tercio de los adultos argentinos con sobrepeso, según estimaciones de la región, convive con reflujo frecuente sin saberlo. El estudio sugiere que la obesidad agrava el daño que el reflujo le hace a las células del esófago, mientras que el tabaco no mostró el mismo efecto. Eso cambia qué factores conviene atacar en la prevención. La pregunta práctica es cuántas personas con reflujo crónico se están haciendo controlar.","quienFirma":"Consorcio internacional de investigación sobre cáncer de esófago (medRxiv, preprint)","confianza":"preprint","consulta":null},"sello":{"hash":"40963003690e5d97cc4c9328c765007389f593c794e4a8154478870e6ac43451","sello":"577dd26e59d9cbafadc463b17cc1ba822816a5da4dfb358ab9765c185ed5debd","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6578272,"aleatorio":"e504aca3fcd7243fddbec8b88f1c51dc96cb1f827ccda23c013f3b302f3c69ab","tiempo":"2026-10-23T18:13:00.000Z"},"nist":{"cadena":2,"pulso":1996329,"salida":"880EE1B503674E57D0E81D7CEC0FFDBB3A3BB5CD5A62E05BB575BBCB9E2DB29F611799CDCF1B120D62E8DF3A39AE0D1B9935A0A198FC708C5974107E51CFF0C4","tiempo":"2026-10-23T18:12:00.000Z"},"noAntes":"2026-10-23T18:13:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 23 18:13:32 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Convergent mutational processes in esophageal and junctional adenocarcinomas across eight countries","descripcion":"The incidence distribution of esophageal adenocarcinoma (EAC) and gastroesophageal junction (GEJ) cancers presents important geographic variations, yet the causes of these differences remain unclear. We analyzed 520 whole genomes from EAC/GEJ tumors across eight countries to examine the mutational forces shaping these cancers and their geographic variation. The mutational landscape was highly similar between EAC and GEJ tumors, and was dominated by signatures SBS17a/b, previously associated with reflux in EAC/GEJ. SBS17a/b were linked to obesity in EAC, supporting an indirect role in exacerbating reflux-mediated mutagenesis. Other established risk factors, such as tobacco smoking, did not yi","pubDate":"2026-10-23","url":"https://www.medrxiv.org/content/10.64898/2026.10.21.26365720v1?rss=1"},"indexado":"2026-10-23T18:12:31.737Z"}}