{"ok":true,"nota":{"id":"d63f9480d9d713d4","slug":"un-receptor-del-higado-frena-la-formacion-de-vasos-sanguineos-anormale-d63f94","titulo":"Un receptor del hígado frena la formación de vasos sanguíneos anormales en la retina de ratones","resumen":"Los investigadores estudiaron el receptor FXR, que responde a los ácidos biliares, en el ojo de ratones con neovascularización de la coroides. Analizaron también datos humanos publicados sobre la degeneración macular.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Harris, C., Nisar, M. A., Seth, A., Oxenrider, A., Bailey, B., Seth, G., Martin, P. M., Jadeja, R. N., Thounaojam, M. C.","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760483v1?rss=1","imagen":"/hoy/portada/d63f9480d9d713d4","tema":"salud","subtemas":["degeneracion macular","vision","receptor fxr","angiogenesis","retina"],"entidades":["bioRxiv","GSE135092"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-23T00:00:00.000Z","indexTs":"2026-10-23T12:03:18.526Z","hash":"14485afdf74ef325f6376fa07ddade4bfa7d1877f1802499c869afc6bab86bd5","tsa":{"time":"Oct 23 12:03:55 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"En tejido de personas con degeneración macular asociada a la edad, la expresión de este receptor aparece bajada. Cuando se pierde su señal en ratones, crecen más vasos anormales en el ojo, un problema central de la forma húmeda de la enfermedad. Hoy se trata con inyecciones contra el VEGF, que no siempre funcionan del todo, así que una vía nueva podría importar. Todavía es un hallazgo en animales y sin ensayos en personas.","quienFirma":"Universidad no especificada en el resumen (preprint en bioRxiv)","confianza":"preprint","consulta":null},"sello":{"hash":"14485afdf74ef325f6376fa07ddade4bfa7d1877f1802499c869afc6bab86bd5","sello":"3a64afcfb0bd7e0dfbaf58e1a4a903b9aba98347a1d5c9577c841c20bc71005e","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6577533,"aleatorio":"c4aba0dd838f5aced1ee3ce73b5a8152f120dc443db083e10a01045483b7000d","tiempo":"2026-10-23T12:03:30.000Z"},"nist":{"cadena":2,"pulso":1995961,"salida":"F41B5D0D554B9AA93D86596521336D547B043E4F52A3C280F10F60EAE511ED1743D3E56670D4E53EB431734AC5B1B8CB5DCF96D1DB26F562D058604979415129","tiempo":"2026-10-23T12:03:00.000Z"},"noAntes":"2026-10-23T12:03:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 23 12:03:55 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Loss of Farnesoid X Receptor Signaling Promotes Choroidal Neovascularization in Mice","descripcion":"Choroidal neovascularization (CNV) is a defining feature of neovascular age-related macular degeneration (nAMD). Although anti-vascular endothelial growth factor (VEGF) therapies suppress neovascular activity, incomplete responses, recurrent leakage, and subretinal fibrosis remain important clinical challenges. The farnesoid X receptor (FXR) is a bile acid-activated nuclear receptor with anti-inflammatory, anti-fibrotic, and anti-angiogenic functions in other tissues, but its role in CNV is unknown. Analysis of publicly available human transcriptomic data (GSE135092) showed FXR expression in the retinal pigment epithelium (RPE)/choroid and significant downregulation in AMD-affected macular R","pubDate":"2026-10-23","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760483v1?rss=1"},"indexado":"2026-10-23T12:03:18.526Z"}}