{"ok":true,"nota":{"id":"d3eb9ca9f86a027c","slug":"entre-adolescentes-la-combinacion-de-genes-cerebro-y-barrio-ayuda-a-an-d3eb9c","titulo":"Entre adolescentes, la combinación de genes, cerebro y barrio ayuda a anticipar experiencias psicóticas angust","resumen":"Siguieron a casi 7.400 chicos del estudio ABCD de Estados Unidos en cuatro momentos de la adolescencia. Usaron aprendizaje automático con datos del cerebro, genética, antecedentes familiares y condiciones del entorno para predecir experiencias psicóticas leves que son persistentes y angustiantes.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Lal, A., Karcher, N. R., Ahern, J., Rigby, A., Rai, S., Cadenhead, K., Linkersdorfer, J., Hagler, D. J., Pecheva, D., Ba","url":"https://www.medrxiv.org/content/10.64898/2026.10.22.26365776v1?rss=1","imagen":"/hoy/portada/d3eb9ca9f86a027c","tema":"salud","subtemas":["salud mental","adolescencia","psicosis","entorno social","neurociencia"],"entidades":["ABCD Study","Estados Unidos","medRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-26T00:00:00.000Z","indexTs":"2026-10-26T16:35:59.047Z","hash":"f7851d72ad5e9efa0282c5f5ad94063f8d08f4ecb179deaf33c453b124292078","tsa":{"time":"Oct 26 16:36:53 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Para predecir si un adolescente va a tener experiencias psicóticas angustiantes y persistentes, el entorno pesa más que la genética o la forma del cerebro. Entre los factores ambientales aparecieron la privación del barrio y el contexto familiar. Esto significa que el lugar donde crecen los chicos puede ser tan importante como lo que traen en sus genes, y que la prevención tendría que mirar la calle y la casa, no solo el consultorio. El estudio es predictivo y no demuestra causas, y los datos vienen de un país con características muy particulares.","quienFirma":"Universidad de Yale (Estados Unidos)","confianza":"preprint","consulta":null},"sello":{"hash":"f7851d72ad5e9efa0282c5f5ad94063f8d08f4ecb179deaf33c453b124292078","sello":"ef19f1b1c60416719c441c13bd5cd42083c7e65afa14248184ac8fdbf7714d8c","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6586719,"aleatorio":"69c104ecd3cb13434712414db5b2ad3c4f3e8c23a6e958cf0c536314410db9d8","tiempo":"2026-10-26T16:36:30.000Z"},"nist":{"cadena":2,"pulso":2000553,"salida":"C52F940F6CB3ED0E0B156BE5FA3EFA2B75E456473C90354367E414D5115CEDF0D632503093B1A864228DF7BF37C390F188E14CB6127FE2E67FC4E9BF01B2FA0B","tiempo":"2026-10-26T16:36:00.000Z"},"noAntes":"2026-10-26T16:36:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 26 16:36:53 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Multimodal Prediction of Distressing and Persistent Psychotic-Like Experiences in Adolescence across Environment, Genetics, and Neuroimaging","descripcion":"Adolescent psychotic-like experiences, particularly those that are distressing and persistent (dpPLEs), may elevate risk for a range of psychiatric disorders, yet the relative predictive contributions of brain structure, genetics, and environment to dpPLEs remain unknown. Using four timepoints from 7,399 children in the Adolescent Brain Cognitive Development (ABCD) Study, we developed stacked ensemble machine-learning models integrating cortical morphometry and whole-brain microstructural properties, polygenic risk scores, family psychiatric history, and childhood environmental factors to predict adolescent dpPLEs. Environmental predictors alone, driven by area deprivation index, neighborhoo","pubDate":"2026-10-26","url":"https://www.medrxiv.org/content/10.64898/2026.10.22.26365776v1?rss=1"},"indexado":"2026-10-26T16:35:59.047Z"}}