{"ok":true,"nota":{"id":"d0d53809d8b2485d","slug":"celulas-del-corazon-cultivadas-en-laboratorio-cambian-de-comportamient-d0d538","titulo":"Células del corazón cultivadas en laboratorio cambian de comportamiento al crecer","resumen":"Científicos cultivaron células cardíacas a partir de células madre humanas y estudiaron cómo las condiciones de cultivo y la expansión alteran su comportamiento. Observaron que pueden volverse hacia un tipo celular asociado a la cicatrización del tejido.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Jiang, H., Malayath, G., Kellogg, A., Debeni Devi, N., Chen, C., Huebsch, N.","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.759862v1?rss=1","imagen":"/hoy/portada/d0d53809d8b2485d","tema":"ciencia","subtemas":["células madre","corazón","cultivo celular","fibrosis cardíaca","medicina regenerativa"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-25T00:00:00.000Z","indexTs":"2026-10-25T18:01:35.781Z","hash":"cac8fa8ac6c556ef72f03e8a60771ffb2205e06f691bfa0b22313b9f93f8f44b","tsa":{"time":"Oct 25 18:01:51 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Las células cardíacas creadas en laboratorio sirven para probar medicamentos y, a futuro, para reparar tejido dañado. Este trabajo muestra que al multiplicarlas pueden cambiar su identidad y acercarse a un estado vinculado a la fibrosis, que endurece el corazón. Para un paciente cardíaco, eso significa que cada paso de cultivo importa y que todavía hay que controlarlo bien. El estudio es un trabajo previo a la publicación formal y sus resultados se hicieron en células, no en personas.","quienFirma":"bioRxiv (preprint, sin revisión por pares)","confianza":"preprint","consulta":null},"sello":{"hash":"cac8fa8ac6c556ef72f03e8a60771ffb2205e06f691bfa0b22313b9f93f8f44b","sello":"0ce38d2a040b04dcf7e0bbcce823c9afdf84334fa5f17a6e35bcb1f0c3e06fc8","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6584008,"aleatorio":"b24e0fb7bae9eeb5f46086253020caeafbc2dc6280a2b6f8e68d77e162756ac8","tiempo":"2026-10-25T18:01:00.000Z"},"nist":{"cadena":2,"pulso":1999198,"salida":"277F6B7941A925ACD230F407EC5F9FCF6663494494416FA0F073B27AE1082B769BAC76032AA9B060175B96F079BDAB7E708FFFA6A639A759BAFF8BC8D83CCF06","tiempo":"2026-10-25T18:01:00.000Z"},"noAntes":"2026-10-25T18:01:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 25 18:01:51 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Mechanical history shapes phenotypic plasticity and fibroblast-autonomous 3D remodeling in iPSC-derived cardiac fibroblasts","descripcion":"Human induced pluripotent stem cell-derived cardiac fibroblasts (iPSC-cFBs) offer a renewable, genetically defined stromal cell source for studying cardiac fibrosis and cardiomyocyte-fibroblast crosstalk during development and disease. Because cardiac fibroblasts are proliferative, expansion of iPSC-cFBs in culture is attractive for applications requiring large cell numbers, including drug screening and tissue engineering. However, phenotypic drift during expansion, particularly premature fibroblast-to-myofibroblast transition (FMT), remains a concern. Here, we investigated how differentiation protocol, mechanical culture history, and serial expansion shape iPSC-cFB phenotype, transforming g","pubDate":"2026-10-25","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.759862v1?rss=1"},"indexado":"2026-10-25T18:01:35.781Z"}}