{"ok":true,"nota":{"id":"ced1f30185c19ad5","slug":"un-nuevo-sistema-de-celulas-t-modulares-permite-controlar-desde-afuera-ced1f3","titulo":"Un nuevo sistema de células T modulares permite controlar desde afuera a qué tumor atacan y cuándo","resumen":"Investigadores desarrollaron una plataforma llamada BRiDGE CAR que usa moléculas adaptadoras intercambiables para dirigir células inmunes modificadas. Probaron cómo influyen el largo del conector y el formato de la adaptadora en la actividad.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Joechner, A. H., Mach, M., Yeh, M., Mehta, R., Khoury, T., Kurangil, E., Yan, J., Barton, D., Li, Z.","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760864v1?rss=1","imagen":"/hoy/portada/ced1f30185c19ad5","tema":"ciencia","subtemas":["inmunoterapia","células car t","cáncer de sangre","biotecnología","terapia celular"],"entidades":["BRiDGE CAR","bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T16:38:44.280Z","hash":"f88eb2f1c02594c68943201ffbe5f9f07c85177ab2fe138778eadd6593bf4819","tsa":{"time":"Oct 22 16:39:44 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Las células T modificadas funcionaron mejor con un conector de largo medio y una adaptadora completa y bivalente, lo que da reglas claras para diseñarlas. Esto podría servir para tratar tumores de sangre que cambian de antígeno y para poder frenar el tratamiento si aparecen efectos adversos. Para pacientes oncológicos de acá, todavía es investigación temprana, sin ensayos clínicos reportados en este trabajo.","quienFirma":"Universidad de Oxford","confianza":"preprint","consulta":null},"sello":{"hash":"f88eb2f1c02594c68943201ffbe5f9f07c85177ab2fe138778eadd6593bf4819","sello":"6d29837e83535178983fd7348ead33b9b0440e2292e54b7b1aaa88821d734a81","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575204,"aleatorio":"ac0f4a6ce509202540c9641abb3a70f7f06eeb36f68a34e1bc3e430369a775da","tiempo":"2026-10-22T16:39:00.000Z"},"nist":{"cadena":2,"pulso":1994801,"salida":"123765DCC46130497358D1E6393BF76FC82D205E2F260DEF171C4887B733C1209F31A193DDD877AB50C2E9F79D0A125A26712AD900F817275AC0E40E5C1C39BC","tiempo":"2026-10-22T16:38:00.000Z"},"noAntes":"2026-10-22T16:39:00.000Z"},"verificacion":{"drand":true,"nist":"inaccesible"},"tsa":{"time":"Oct 22 16:39:44 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Development and design rules for a modular human peptide-tag adaptor CAR T cell system","descripcion":"CAR T cells are highly effective in haematological malignancies, but limited post-infusion control and tumour antigen heterogeneity remain major challenges. Modular CAR systems address these limitations using interchangeable adaptor molecules (AM) to control CAR T cell engagement and redirect targeting toward different antigens, yet the design principles underlying effective modular function remain undefined. We present our modular platform, BRiDGE CAR, and systematically examine how CAR and adaptor configuration influence activity. BRiDGE CAR activity was influenced by CAR hinge length and adaptor format and valency; a medium-length hinge combined with a full-length, bivalent adaptor suppor","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760864v1?rss=1"},"indexado":"2026-10-22T16:38:44.280Z"}}