{"ok":true,"nota":{"id":"ccbef1089f20e250","slug":"descubren-una-proteina-humana-que-sirve-de-puerta-de-entrada-a-nuevos--ccbef1","titulo":"Descubren una proteína humana que sirve de puerta de entrada a nuevos virus de origen animal","resumen":"Un equipo identificó una proteína de los vasos sanguíneos que permite entrar a células humanas a varios virus de la familia del Nipah y el Langya. Con microscopía de alta resolución mostraron cómo se engancha el virus y qué variaciones genéticas cambian la susceptibilidad.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Zhao, Z., Tran, P., Li, N., Ou, L., Song, J., Sibilo, M., Castro, M., Chowdhury, A., Bohl, J. A., Wu, J. M., Do, T. T., ","url":"https://www.biorxiv.org/content/10.64898/2026.11.01.763137v1?rss=1","imagen":"/hoy/portada/ccbef1089f20e250","tema":"salud","subtemas":["virus zoonoticos","virus langya","receptores celulares","vigilancia sanitaria","pandemias"],"entidades":["Langya virus","EPCR","Nipah"],"formato":"dato","entretenimiento":false,"pubTs":"2026-11-02T00:00:00.000Z","indexTs":"2026-11-02T21:02:54.563Z","hash":"6b6ea98405ae62991cfdb58417f8a83c89c15b2a18b2a9d2fe1c4f7c3c316f97","tsa":{"time":"Nov  2 21:03:10 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"El estudio muestra que el virus Langya usa la proteína EPCR para entrar a la célula, y que pequeñas diferencias genéticas entre personas y entre animales determinan quién es más vulnerable. Para la salud pública esto sirve para vigilar qué especies animales pueden transmitir el virus y para pensar futuras defensas. Un virus con potencial pandémico deja de ser un misterio cuando se conoce su llave. Saber cuál es esa llave es el primer paso para no quedar a merced de la próxima sorpresa zoonótica.","quienFirma":"Instituto Vacunas Chile / Universidad de Chile","confianza":"preprint","consulta":null},"sello":{"hash":"6b6ea98405ae62991cfdb58417f8a83c89c15b2a18b2a9d2fe1c4f7c3c316f97","sello":"45b32fcb68e339c1945db72c251d2d4931274500c63ad2483ffefe663a47e82f","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6607412,"aleatorio":"b82811149e1ff778e72e08ad3486e6fdd7930f5e5e94f971a07760805cc0e246","tiempo":"2026-11-02T21:03:00.000Z"},"nist":{"cadena":2,"pulso":2010639,"salida":"D5B8E3AE0CC2A63BA754C217D57DF04E57CD6AB6386845EEE11F24E1EF5095A29117C3854D3F203ED33254CDE4AF88046CDEB28EF096BFED75E6A468AC755FFB","tiempo":"2026-11-02T21:01:00.000Z"},"noAntes":"2026-11-02T21:03:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Nov  2 21:03:10 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Endothelial protein C receptor is an entry receptor for Langya and related parahenipaviruses","descripcion":"Langya virus is a zoonotic parahenipavirus with pandemic potential that causes acute febrile illness in people. We identified endothelial protein C receptor (EPCR) as an entry receptor for Langya, Wenzhou, and Mojiang parahenipaviruses. A 3.1 [A] cryo-electron microscopy structure reveals that Langya attachment glycoprotein engages EPCR through a site distinct from that of the ephrin binding site of Nipah G. This binding mode resembles those of protein C and a malarial adhesin, demonstrating convergent evolution. Interface substitutions abolish entry, whereas natural variation explains differential human EPCR use and predicts receptor compatibility across 26 animal species. These findings es","pubDate":"2026-11-02","url":"https://www.biorxiv.org/content/10.64898/2026.11.01.763137v1?rss=1"},"indexado":"2026-11-02T21:02:54.563Z"}}