{"ok":true,"nota":{"id":"cc2fedb07b323033","slug":"descubrieron-regiones-del-adn-lejos-del-gen-del-colesterol-que-tambien-cc2fed","titulo":"Descubrieron regiones del ADN lejos del gen del colesterol que también regulan cuánto LDL se produce","resumen":"Un equipo usó herramientas de edición genética para revisar sistemáticamente las zonas no codificantes del gen LDLR, que regula la cantidad de colesterol LDL en sangre. Identificaron elementos reguladores además de los ya conocidos.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Vyas, H. S., Leix, K., Burugula, B. B., Paye, S. M., Raut, C., Speliotes, E. K., Emmer, B. T.","url":"https://www.biorxiv.org/content/10.64898/2026.10.22.761041v1?rss=1","imagen":"/hoy/portada/cc2fedb07b323033","tema":"salud","subtemas":["colesterol","genética","enfermedad cardiovascular","regulación génica","edición genética"],"entidades":["bioRxiv","gen LDLR"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-25T00:00:00.000Z","indexTs":"2026-10-25T13:26:04.362Z","hash":"47f3c5391d5cdb9eed409a06df6771b567f5788c950b38658dd5401d58832792","tsa":{"time":"Oct 25 13:26:58 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"El colesterol LDL alto es uno de los principales factores de riesgo de infarto y ACV, y su nivel depende en parte de un gen que hasta ahora se entendía solo a medias. Este estudio muestra que hay muchas más zonas del ADN que influyen en ese gen, algo que puede cambiar cómo se buscan tratamientos futuros. Para quien tiene antecedentes familiares de colesterol alto, esto significa que la explicación genética es más compleja de lo que se pensaba. El trabajo, por ahora, se hizo en células de laboratorio y no en personas.","quienFirma":"Institución no identificada en el resumen disponible","confianza":"preprint","consulta":null},"sello":{"hash":"47f3c5391d5cdb9eed409a06df6771b567f5788c950b38658dd5401d58832792","sello":"e035f48f165e6ac84d65b25a92ee77a388dba2ba722456ac040b32470596f0e6","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6583459,"aleatorio":"0a139b88186ff9ac4061b9ae2a2fd60d7a03c380f08f96a5b763a564cd5f8535","tiempo":"2026-10-25T13:26:30.000Z"},"nist":{"cadena":2,"pulso":1998923,"salida":"CAACCBC90B253254A2BA37D2F2DAD32D412D022A909309D40D4961AE24D8236EAD656C06ED2DE2604FB73EFC57434602CEDA74C12D692B1DB5605BA381C0ED58","tiempo":"2026-10-25T13:26:00.000Z"},"noAntes":"2026-10-25T13:26:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 25 13:26:58 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Multimodal functional characterization of the LDLR noncoding landscape","descripcion":"The expression level of the low-density lipoprotein receptor (LDLR) gene is a critical determinant of circulating low-density lipoprotein concentrations and the corresponding risk of atherosclerotic cardiovascular disease. While the importance of sterol response elements in LDLR transcriptional regulation has been firmly established, the functional contribution of other potential cis-regulatory elements (CREs) remains poorly understood. In this study, we developed and applied a variety of high throughput functional genomic tools to systematically interrogate the noncoding space at the LDLR locus. These included saturation CRISPR nuclease, CRISPR activation, and CRISPR inhibition screening as","pubDate":"2026-10-25","url":"https://www.biorxiv.org/content/10.64898/2026.10.22.761041v1?rss=1"},"indexado":"2026-10-25T13:26:04.362Z"}}