{"ok":true,"nota":{"id":"cb037d951125376a","slug":"un-sonido-debil-que-se-repite-en-el-tiempo-puede-activar-celulas-con-d-cb037d","titulo":"Un sonido débil que se repite en el tiempo puede activar células, con demora","resumen":"Investigadores expusieron células endoteliales humanas a pulsos acústicos débiles y midieron cambios de calcio dentro de ellas. Compararon esa respuesta con la de estímulos mecánicos más fuertes.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Noh, Y. H., Ho, I.-T., Kosters, M., Runge, K., Ding, X., Deymier, P. A., Kim, M.","url":"https://www.biorxiv.org/content/10.64898/2026.10.18.759952v1?rss=1","imagen":"/hoy/portada/cb037d951125376a","tema":"salud","subtemas":["ruido ambiental","celulas endoteliales","calcio celular","salud cardiovascular","contaminacion acustica"],"entidades":["células endoteliales humanas"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-23T06:48:38.804Z","hash":"840043c96765188a628f2412ad793667aa3cbe072da1b31c33cc96c6cf1ef2c8","tsa":{"time":"Oct 23 06:48:59 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"motor","registro":"hallazgo","porQueImporta":"Vivimos rodeados de ruido urbano, y las vinculaciones epidemiológicas con problemas cardiovasculares y metabólicos ya eran conocidas, pero no estaba claro cómo se traducía eso dentro de las células. Este trabajo sugiere que las células acumulan los sonidos débiles y responden con retraso, como si sumaran pequeñas señales. Para quien vive en una ciudad ruidosa, es una pista de que el ruido constante podría pesar de manera silenciosa. Todavía se trata de un hallazgo en células aisladas, no en personas.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":{"pregunta":"¿Te preocupa el ruido de tu barrio o de tu trabajo?"}},"sello":{"hash":"840043c96765188a628f2412ad793667aa3cbe072da1b31c33cc96c6cf1ef2c8","sello":"968879e16ef33a97e9dbcadeb48abc3b86f2e8375044945503fbc48ef65d2c3d","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6576903,"aleatorio":"8e583525a288ba13cde66d0d6539d282d867cec58f75a0217a855687a27f9649","tiempo":"2026-10-23T06:48:30.000Z"},"nist":{"cadena":2,"pulso":1995651,"salida":"AA82134D649B7B25F10D77FD67053808011261EF94B49E048C931DF7D357E824C95C66604E50CE6E37F934A39EE493177DEA66983586EA3E4667145C3C8919D6","tiempo":"2026-10-23T06:48:00.000Z"},"noAntes":"2026-10-23T06:48:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 23 06:48:59 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Temporal Integration of Weak Acoustic Stress Leads to Delayed Cellular Responses","descripcion":"Sound is a pervasive physical stimulus with beneficial or adverse effects depending on exposure. While controlled sound-based interventions such as ultrasound have demonstrated clinical utility, epidemiological studies link chronic environmental noise to increased cardiovascular and metabolic risk. Despite these associations, how weak sound is sensed and integrated at the cellular level remains unclear. Here, we investigate cellular responsiveness to acoustic pulse-wave stimulation in human endothelial cells, using intracellular calcium changes as a readout of cellular activation. Cellular responses to acoustic stimulation were compared with over-threshold mechanical stimulation. Over-thresh","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.18.759952v1?rss=1"},"indexado":"2026-10-23T06:48:38.804Z"}}