{"ok":true,"nota":{"id":"c9c43d3b1ec874ca","slug":"una-dieta-rica-en-grasas-poliinsaturadas-cambia-la-sensibilidad-de-las-c9c43d","titulo":"Una dieta rica en grasas poliinsaturadas cambia la sensibilidad de las defensas a un tipo de muerte celular","resumen":"Investigadores alimentaron ratones con una dieta enriquecida en grasas muy insaturadas y analizaron la composición lipídica de sus células inmunes. Encontraron que la dieta modifica esas grasas y, con ello, la susceptibilidad de las células a la ferroptosis, una forma de muerte celular por oxidación.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Morgan, P. K., Xu, Y., Collins, T. J. C., Bertuzzo Veiga, C., Mellet, N. A., Huynh, K., Meikle, P., Murphy, A. J., Lanca","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760583v1?rss=1","imagen":"/hoy/portada/c9c43d3b1ec874ca","tema":"ciencia","subtemas":["ferroptosis","grasas poliinsaturadas","sistema inmune","alimentación","muerte celular"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-21T22:39:37.287Z","hash":"4e00c62bfe2957830f878246faec092b53d467fd92700892360f062a62ded9f5","tsa":{"time":"Oct 21 22:40:36 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"La ferroptosis es un mecanismo que se estudia como posible blanco para tratar cáncer, y lo que se come podría influir en cuán sensibles son las defensas del cuerpo a él. Esto sugiere que la alimentación no es un factor neutro cuando se piensan terapias contra enfermedades graves. Para alguien de acá, la lectura práctica es cautela: que una dieta cambie las grasas de las células no equivale a que sirva para curar nada. El experimento fue en ratones, y trasladar estos resultados a personas requiere estudios clínicos que todavía no existen.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"4e00c62bfe2957830f878246faec092b53d467fd92700892360f062a62ded9f5","sello":"87c7ef4eba712edbe0c4d25bac33dbe7dd22113effa32db26f993499404d84e4","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6573046,"aleatorio":"f71b3db032f12c8ae2d90f38aa37ddc03a4bd072f8a3317f2962e831c62e695d","tiempo":"2026-10-21T22:40:00.000Z"},"nist":{"cadena":2,"pulso":1993728,"salida":"DBB029F00A75EEAA9AF69BB0B3207AD12D5A4EDD2136CB35D25CB332980962472F1AFBB0B247EB7DF6BE52045BC8A63F1D14E2719075ECD2BA39DE673005A0E1","tiempo":"2026-10-21T22:39:00.000Z"},"noAntes":"2026-10-21T22:40:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 21 22:40:36 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"A diet enriched in highly poly-unsaturated fatty acids alters immune cell lipid composition and ferroptosis susceptibility","descripcion":"Ferroptosis is a regulated form of cell death that is dependent upon the peroxidation of phospholipids containing poly-unsaturated fatty acids (PL-PUFAs), particularly those with 4 or more double bonds. PL-PUFA content is dramatically different between immune cell types which directly influences their sensitivity to ferroptosis. Modulating the PL-PUFA content of various cells is becoming an attractive approach to increase the efficacy of therapies designed to target ferroptosis. In this study we aimed to determine whether a diet enriched in highly unsaturated PUFAs alters immune cell lipid composition and, consequently, the susceptibility to ferroptosis. To address this, mice were fed either","pubDate":"2026-10-21","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760583v1?rss=1"},"indexado":"2026-10-21T22:39:37.287Z"}}