{"ok":true,"nota":{"id":"c8fe81f05b34c8ba","slug":"buscan-los-genes-que-hacen-que-algunos-pacientes-con-quimioterapia-suf-c8fe81","titulo":"Buscan los genes que hacen que algunos pacientes con quimioterapia sufran daño en el corazón","resumen":"Investigadores crearon un modelo en laboratorio con distintos tipos de células cardíacas para observar cómo reaccionan a dos quimioterápicos. El objetivo es identificar variantes genéticas asociadas al daño cardiovascular.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"McIntire, E., Barr, K. A., Gonzales, N. M., Allen, O. L., Burnett, J. E., Gilad, Y.","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759549v1?rss=1","imagen":"/hoy/portada/c8fe81f05b34c8ba","tema":"salud","subtemas":["quimioterapia","cardiotoxicidad","genética","cáncer","efectos adversos"],"entidades":[],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T16:38:44.280Z","hash":"5456d46920368fc88fc2d0995928dec2d2060c10089885d7266fe5ceb1d2d8c3","tsa":{"time":"Oct 22 16:39:28 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Algunos pacientes que reciben doxorubicina o 5-fluorouracilo tienen efectos cardíacos tan serios que deben suspender el tratamiento, lo que puede hacerlo menos eficaz. Saber qué genes influyen permitiría anticipar quién corre más riesgo antes de empezar. Hoy esa predicción no existe, y la quimioterapia se aplica a ciegas en ese punto.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"5456d46920368fc88fc2d0995928dec2d2060c10089885d7266fe5ceb1d2d8c3","sello":"6e1a6b6f618be5fe579a77a55f504dff29a30cba06f8324121deada1582237e8","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575204,"aleatorio":"ac0f4a6ce509202540c9641abb3a70f7f06eeb36f68a34e1bc3e430369a775da","tiempo":"2026-10-22T16:39:00.000Z"},"nist":{"cadena":2,"pulso":1994801,"salida":"123765DCC46130497358D1E6393BF76FC82D205E2F260DEF171C4887B733C1209F31A193DDD877AB50C2E9F79D0A125A26712AD900F817275AC0E40E5C1C39BC","tiempo":"2026-10-22T16:38:00.000Z"},"noAntes":"2026-10-22T16:39:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 16:39:28 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Genetic Determinants of Cell-Type-Specific Responses to Cardiotoxic Chemotherapeutic Agents","descripcion":"Doxorubicin (DOX) and 5-fluorouracil (5-FU) are effective for treating a variety of cancers, yet many patients taking these drugs experience adverse cardiovascular events that are severe enough to pause treatment, often prolonging the course of chemotherapy and reducing its efficacy. Individual risk for drug-induced cardiotoxicity is likely mediated, at least in part, by genetic variants that control how the heart and vasculature respond to drug-induced perturbations. To identify loci associated with drug-induced cardiotoxicity, we developed an in vitro model that allows us to characterize the effects of chemotherapeutic drugs on a wide range of cardiac cell types, including cardiomyocytes, ","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759549v1?rss=1"},"indexado":"2026-10-22T16:38:44.280Z"}}