{"ok":true,"nota":{"id":"c63fee68d408f092","slug":"una-combinacion-de-estatinas-con-un-compuesto-inflamatorio-dano-los-ri-c63fee","titulo":"Una combinación de estatinas con un compuesto inflamatorio dañó los riñones de ratones","resumen":"Investigadores probaron si ciertas estatinas, combinadas con un compuesto producido por macrófagos inflamados, dañan las células del riñón. En ratones tratados con estatinas, una dosis baja de una sustancia inflamatoria desencadenó una lesión renal aguda.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Kim, C. H., Wang, H. J., Cho, Y., Lee, J. H., Yoon, J., Kim, H.-Y., Jung, Y., Lee, H., Choi, H. Y., Lee, J.-Y., Gee, H. ","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759612v1?rss=1","imagen":"/hoy/portada/c63fee68d408f092","tema":"salud","subtemas":["estatinas","lesion renal aguda","inflamacion","efectos adversos de medicamentos","colesterol"],"entidades":["estatinas","ratones"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T21:54:18.823Z","hash":"fc5e97da492fb880171cc6c613de424015d9cd415e37e505628fc5a5f013cceb","tsa":{"time":"Oct 22 21:55:19 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Las estatinas se recetan a millones de personas para bajar el colesterol, y que un proceso inflamatorio pueda volverlas peligrosas para el riñón ayuda a explicar casos de daño que hoy no tienen una causa clara. Para un paciente argentino, esto sugiere que el estado inflamatorio del cuerpo podría importar tanto como la pastilla en sí. El estudio se hizo en células y ratones, así que todavía no dice cuánto pesa esto en personas, y esa es la pregunta que falta responder.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"fc5e97da492fb880171cc6c613de424015d9cd415e37e505628fc5a5f013cceb","sello":"467b9527629f267f24f1858087d44314f07855e7c47b261b88cfe3f53a788007","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575836,"aleatorio":"a8739c6f28d7e03ed191a881119536d56c373334288c8dc3d26ef33eb54db44f","tiempo":"2026-10-22T21:55:00.000Z"},"nist":{"cadena":2,"pulso":1995117,"salida":"932C769A8B73E2CC53835512DA1C7CF78DC4B06757B136D8DCC28C89B61C25ED52E0DD74B99E06F83F83805D89C905466FC5BF54DA4D037DEA5F5312DBA4C659","tiempo":"2026-10-22T21:54:00.000Z"},"noAntes":"2026-10-22T21:55:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 21:55:19 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Macrophage-Derived 25-Hydroxycholesterol Drives Statin-Associated Acute Kidney Injury","descripcion":"Although acute kidney injury (AKI) has been implicated as a potential adverse effect of statin therapy, experimental evidence supporting this association remains limited. Here, we investigated whether elevated levels of 25-hydroxycholesterol (25-HC), an oxysterol produced by activated macrophages and monocytes, increase susceptibility to statin-induced AKI. We found that atorvastatin and fluvastatin induced cell death in proximal tubular cells when combined with 25-HC. Consistently, administration of low-dose lipopolysaccharide triggered AKI in statin-treated mice. Mechanistically, impaired protein prenylation disrupted the autophagosome-lysosome pathway in proximal tubular cells. AKI was at","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759612v1?rss=1"},"indexado":"2026-10-22T21:54:18.823Z"}}