{"ok":true,"nota":{"id":"c2195e3831928e92","slug":"una-prueba-rapida-con-pocos-datos-detecta-si-una-biblioteca-genetica-f-c2195e","titulo":"Una prueba rápida con pocos datos detecta si una biblioteca genética falla antes de gastar más","resumen":"Se presentó un flujo de control de calidad que usa unos pocos miles de lecturas de nanoporos para revisar muestras antes de la secuenciación profunda. Permite detectar errores de preparación a tiempo para corregirlos.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Liu, H., Kim, J. J.","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.760194v1?rss=1","imagen":"/hoy/portada/c2195e3831928e92","tema":"ciencia","subtemas":["secuenciacion","laboratorio","control de calidad","genomica"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-24T00:00:00.000Z","indexTs":"2026-10-24T15:36:22.700Z","hash":"f7f34c177c65e21a7860b01df283c363e538fda7a7822a4210b6cbe0f931b9e3","tsa":{"time":"Oct 24 15:36:50 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Hoy muchos experimentos de genética se descubren mal recién después de gastar semanas y mucho dinero en secuenciación completa. Un control rápido ahorra recursos a laboratorios de todo el mundo, incluidos los de la región, donde cada reactivo cuesta. Es una mejora práctica de método más que un descubrimiento sobre la vida, y eso la vuelve útil para quien trabaja con el laboratorio día a día. El trabajo todavía no fue revisado por pares.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"f7f34c177c65e21a7860b01df283c363e538fda7a7822a4210b6cbe0f931b9e3","sello":"ca01c8dffef618f5ea4be6858b214da36cbf8153f1ac3c67760b0026f306b06e","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6580838,"aleatorio":"d8ef5a9dd5dcb7ecde960120181f6d2da35de75b230ed4ca2c75f2e3041031ed","tiempo":"2026-10-24T15:36:00.000Z"},"nist":{"cadena":2,"pulso":1997612,"salida":"0525492476BBCEBBD988C497DA276C7A3F76D40712E146911682FB4E3ECC1DD0525787CE88330588DA3B0EF9D7839EBA4BAC598FA8667FB3007E6D6E35A002BD","tiempo":"2026-10-24T15:35:00.000Z"},"noAntes":"2026-10-24T15:36:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 24 15:36:50 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"ONT-LibQC: rapid quality control of chromatin assay libraries using shallow nanopore sequencing","descripcion":"A next-generation sequencing (NGS) library for genomic assays can have an acceptable DNA concentration and size distribution yet lack the biological signal of interest. For chromatin assays, such as CUT&RUN and Micro-C, such problems often become apparent only after deep Illumina sequencing, delaying troubleshooting and protocol optimization. Here, we present ONT-LibQC, a workflow that uses a few thousand Oxford Nanopore Technologies (ONT) sequencing reads to examine finished libraries before deep sequencing. It reconstructs library molecules, identifies adapters and indexes, and assesses fragment sizes and the enrichment of biological signal. For CUT&RUN libraries, shallow, approximately 3,","pubDate":"2026-10-24","url":"https://www.biorxiv.org/content/10.64898/2026.10.19.760194v1?rss=1"},"indexado":"2026-10-24T15:36:22.700Z"}}