{"ok":true,"nota":{"id":"c02b8486c423da1a","slug":"ratones-machos-sin-experiencia-pueden-aprender-a-cuidar-crias-en-una-s-c02b84","titulo":"Ratones machos sin experiencia pueden aprender a cuidar crías en una semana","resumen":"Investigadores expusieron ratones machos adultos sin experiencia parental a crías durante siete días. Los que nunca habían sido padres empezaron a cuidarlas, y encontraron neuronas clave en el hipotálamo para ese cambio.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"O'Neill, P. T., Yan, R., Wang, Y., Wang, Q., Yin, L., Lhamo, G., Rhodes, D. J., Little, J., Cheng, H., Chen, L., Shoham,","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760822v1?rss=1","imagen":"/hoy/portada/c02b8486c423da1a","tema":"ciencia","subtemas":["conducta parental","hipotalamo","neuronas","ratones","plasticidad cerebral"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T10:38:41.125Z","hash":"b1641678db7d247fac3ed67bb4eda08d68d29727f914dda58936526993e1ca28","tsa":{"time":"Oct 22 10:39:24 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"En siete días, machos que no habían cuidado nunca a una cría empezaron a hacerlo, y ese cambio dependió de un grupo específico de neuronas del hipotálamo. Silenciarlas impedía que el comportamiento apareciera, y activarlas lo promovía. Para alguien de acá, la conducta de cuidado no sería algo fijo, sino algo que el cerebro puede aprender con la exposición. Esto se observó en ratones, y trasladarlo a personas exige muchísima más investigación.","quienFirma":"bioRxiv (preprint, sin revisión por pares)","confianza":"preprint","consulta":null},"sello":{"hash":"b1641678db7d247fac3ed67bb4eda08d68d29727f914dda58936526993e1ca28","sello":"a62fda998b93808bd5f31dbf08a9658b970b59f658355bc82e429297dc3087d2","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6574484,"aleatorio":"17f8dc6691055e17d3340945fc697b1d14385d774dc400926b289d0664c160fb","tiempo":"2026-10-22T10:39:00.000Z"},"nist":{"cadena":2,"pulso":1994441,"salida":"917B00588BBAF41DD8C461E7D93EA47DC73C00983776285722380061C2505D68D1C49D178A1E9E1A422EEA35DB6367141AB79828DD0F9592CE1805F752B02469","tiempo":"2026-10-22T10:32:00.000Z"},"noAntes":"2026-10-22T10:39:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 10:39:24 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Hypothalamic plasticity for alloparenting in male mice","descripcion":"Repeated exposure to young can induce caregiving in virgin female mice, a phenomenon known as pup sensitization, but whether virgin males can similarly acquire parental behavior and the neural mechanisms underlying this transition remain unclear. We show that 7 days of continuous pup exposure reliably converts virgin adult male mice to a parental state. This transition requires calcitonin receptor (CalcR)-expressing neurons in the medial preoptic area (MPOA): silencing MPOACalcR neurons disrupts both the acquisition and expression of paternal behavior, whereas optogenetic activation of GABAergic MPOACalcR neurons promotes caregiving in virgin males. Longitudinal two-photon calcium imaging re","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760822v1?rss=1"},"indexado":"2026-10-22T10:38:41.125Z"}}