{"ok":true,"nota":{"id":"bf1f7d614690d6ba","slug":"cambios-en-las-marcas-del-adn-del-cerebro-a-medida-que-envejece-bf1f7d","titulo":"Cambios en las marcas del ADN del cerebro a medida que envejece","resumen":"Estudio en ratones que analiza por tipo de célula dos modificaciones químicas del ADN, la metilación y la hidroximetilación, y su relación con la expresión de los genes durante el envejecimiento cerebral.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Ocanas, S. R., Hoolehan, W., Pham, K. D., Wright, C. T., Tooley, K. B., Ansere, V., Machalinski, A. H., Stanford, D. R.,","url":"https://www.biorxiv.org/content/10.64898/2026.10.15.757659v1?rss=1","imagen":"/hoy/portada/bf1f7d614690d6ba","tema":"ciencia","subtemas":["epigenética","envejecimiento cerebral","metilación del adn","expresión génica","ratones"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-21T10:34:42.642Z","hash":"1cd7e14cb07ba161de30d022a981e5f9c824bbbd4c7ed18a6f67bb8cc80c0d70","tsa":{"time":"Oct 21 10:35:26 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Las células del cerebro mantienen su identidad gracias a marcas químicas sobre el ADN que activan o apagan genes. Este trabajo separa dos de esas marcas, que a veces tienen efectos opuestos, algo que estudios previos mezclaban. Para alguien de acá, la consecuencia es que todavía no se sabe si el envejecimiento hace perder identidad a las neuronas o si simplemente se adaptan. El trabajo es en ratones, y trasladarlo a personas requiere más investigación.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"1cd7e14cb07ba161de30d022a981e5f9c824bbbd4c7ed18a6f67bb8cc80c0d70","sello":"e9efe5cad02e5ebedae59097b4d4b0c6205b0ba7d677d73a87dbea8c51327287","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6571596,"aleatorio":"2c36e18ae584b00d9a77fc6ee91bac2d1e017f0e506ff9533e9d65bd838a5467","tiempo":"2026-10-21T10:35:00.000Z"},"nist":{"cadena":2,"pulso":1993004,"salida":"23161ED84C8333D8735666F0B82E202695897452E701B068B63EF76A2E59D22F1B819FE2CF27AC06B5894483118E32D36F4246E7C1D82B4789A57D7588B065D3","tiempo":"2026-10-21T10:35:00.000Z"},"noAntes":"2026-10-21T10:35:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 21 10:35:26 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"A new epigenetic framework for DNA methylation, hydroxymethylation, and gene expression during brain aging.","descripcion":"DNA modifications are epigenetic marks added directly to DNA bases that can stably or dynamically regulate gene expression, allowing cells to maintain their identity while also having flexibility to adapt to changes in their environment1. Aging is often thought to disrupt this regulation, causing cells to lose their identities and functionally decline2. However, testing this hypothesis has been difficult because most studies analyze tissues containing mixed cell types and do not distinguish the two most abundant DNA modifications, 5-methylcytosine and 5-hydroxymethylcytosine, which often have opposing relationships with gene expression3. Here we show that, across major cell types in the mous","pubDate":"2026-10-21","url":"https://www.biorxiv.org/content/10.64898/2026.10.15.757659v1?rss=1"},"indexado":"2026-10-21T10:34:42.642Z"}}