{"ok":true,"nota":{"id":"bee70b2210d98802","slug":"un-tipo-de-nervio-sensible-al-tacto-se-dana-en-la-diabetes-y-el-efecto-bee70b","titulo":"Un tipo de nervio sensible al tacto se daña en la diabetes, y el efecto depende del sexo","resumen":"Investigadores estudiaron en ratones un tipo específico de neurona sensorial que percibe el tacto suave y la vibración, en condiciones de diabetes. Compararon machos y hembras para ver cómo cambia el daño en cada caso.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Rastoldo, G., Jaafar, A. K., Bringart, M., Bourane, S.","url":"https://www.biorxiv.org/content/10.64898/2026.10.24.761523v1?rss=1","imagen":"/hoy/portada/bee70b2210d98802","tema":"salud","subtemas":["diabetes","neuropatia diabetica","sistema nervioso","diferencias por sexo","investigacion en ratones"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-25T00:00:00.000Z","indexTs":"2026-10-25T18:18:47.215Z","hash":"d92501defed3ed0afa3e4e2c98cfd21600adbf46b46c8835aecd97cf44a4d1c1","tsa":{"time":"Oct 25 18:19:08 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Hasta ahora se pensaba que la pérdida de sensibilidad en pies y manos de quien tiene diabetes era un daño parejo en los nervios. Este trabajo sugiere que ciertos nervios se afectan de forma distinta según el sexo, lo que podría explicar por qué no todos sienten lo mismo. Para una persona con diabetes en Argentina, eso abre la puerta a tratamientos que no sirvan igual para todos. El resultado todavía viene de ratones y falta confirmarlo en personas.","quienFirma":"bioRxiv (preprint)","confianza":"preprint","consulta":null},"sello":{"hash":"d92501defed3ed0afa3e4e2c98cfd21600adbf46b46c8835aecd97cf44a4d1c1","sello":"043fad2743c39a0198fd4053f505151f2d11e9a0c0b4152e2390d8d86385d5ca","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6584043,"aleatorio":"b5fd9bd83b3a4f54b7160d99b2be7ebb03f3a6d13c9fc67038a3cfb58d7a0c14","tiempo":"2026-10-25T18:18:30.000Z"},"nist":{"cadena":2,"pulso":1999215,"salida":"35343A11C1A43B552037A87872C3BBBA5198EE4A0D8BA56CDD0700BC2D12F3BC90BF7CBD775200EDD1DE14863960E13B9824460EE0F61C350371913ECEB95264","tiempo":"2026-10-25T18:18:00.000Z"},"noAntes":"2026-10-25T18:18:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 25 18:19:08 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Sex-dependent Aβ RA-Low threshold mechanoreceptors alteration in diabetic conditions","descripcion":"Diabetic peripheral neuropathy (DPN) is a major complication of diabetes that profoundly affects quality of life, yet its cellular mechanisms remain poorly defined. Neuropathic pain and sensory loss in DPN are thought to arise from progressive alterations in peripheral nerves usually described as a glove-stocking distribution, but the specific contribution of sensory neuron subtypes has received little attention. Here, we focused on A{beta} rapidly adapting low-threshold mechanoreceptors (A{beta} RA-LTMRs), a large-diameter sensory neuron subtype best known for mediating touch and vibratory sensation. Using an intersectional genetic approach, we generated AdvillinCre; MafAFlpO; Ai65 mice, al","pubDate":"2026-10-25","url":"https://www.biorxiv.org/content/10.64898/2026.10.24.761523v1?rss=1"},"indexado":"2026-10-25T18:18:47.215Z"}}