{"ok":true,"nota":{"id":"baf9dd438aabed0a","slug":"una-proteina-de-la-mitocondria-seria-clave-para-formar-peroxisomas-seg-baf9dd","titulo":"Una proteína de la mitocondria sería clave para formar peroxisomas, según un estudio con células humanas","resumen":"Científicos observaron que la proteína PEX14 se ubica naturalmente en las mitocondrias y no solo de forma anormal, como se pensaba. Según el trabajo, esa presencia contribuye a la formación de los peroxisomas, pequeños orgánulos celulares.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Nemeita, B., Hammann, A., Karki, S., Soykan, T., Wieland, L., Lehmann, M., Thoms, S.","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759530v1?rss=1","imagen":"/hoy/portada/baf9dd438aabed0a","tema":"ciencia","subtemas":["biologia celular","peroxisomas","mitocondrias","enfermedades raras","genetica"],"entidades":["PEX14"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-21T16:39:55.345Z","hash":"0b46c26e156046ad1b447972e24a8546f24b3bb04da16149e1a73baae8b11164","tsa":{"time":"Oct 21 16:40:53 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Hasta ahora se creía que la presencia de esta proteína en las mitocondrias era un error de las células enfermas, y eso guiaba cómo se entendían algunas enfermedades raras. Si es parte del funcionamiento normal, cambia la forma de pensar el origen de esos cuadros. Para alguien sin formación en el tema, es un cambio de mirada sobre cómo se arman las células. El estudio aún no está revisado por pares y se basa en modelos de laboratorio.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"0b46c26e156046ad1b447972e24a8546f24b3bb04da16149e1a73baae8b11164","sello":"96aae9c3c36e4311ead88ce83349f280035b6562a7570d6c974e3ada7a20e1fb","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6572327,"aleatorio":"d83e967e4c34cdf1b7eff62e6ba3c2a80c045b63fe1850f9291b003cd2f10aa6","tiempo":"2026-10-21T16:40:30.000Z"},"nist":{"cadena":2,"pulso":1993369,"salida":"46902ECFB36399313FFB65B445E71293DBF949380A38ED8B222CF72E430037F81238506B220BC468F19AAF1083C6EF424CA492E1A3404D8F36DA9E790C7B253D","tiempo":"2026-10-21T16:40:00.000Z"},"noAntes":"2026-10-21T16:40:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 21 16:40:53 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Mitochondrial PEX14 supports peroxisome biogenesis","descripcion":"Peroxisomes are essential for cellular homeostasis and human health due to their central metabolic and physiological functions. The peroxisomal membrane protein PEX14 is indispensable for matrix protein import into peroxisomes. Recent studies support a hybrid model in which pre-peroxisomal vesicles originating from both, mitochondria and the endoplasmic reticulum, fuse to generate peroxisomes. PEX14 has repeatedly been observed at mitochondria in biogenesis disease models or upon protein overexpression, but such localization has generally been interpreted as aberrant mislocalization. Whether endogenous PEX14 naturally localizes to mitochondria and contributes to peroxisome biogenesis has rem","pubDate":"2026-10-21","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759530v1?rss=1"},"indexado":"2026-10-21T16:39:55.345Z"}}