{"ok":true,"nota":{"id":"b9c6bc1c6b5422fd","slug":"virus-gigantes-que-infectan-bacterias-del-intestino-humano-tienen-prot-b9c6bc","titulo":"Virus gigantes que infectan bacterias del intestino humano tienen proteínas que tocan la pared celular","resumen":"Analizaron casi 7.200 genomas de fagos gigantes, virus que infectan bacterias. Encontraron gran variedad de proteínas vinculadas a la envoltura bacteriana, sobre todo en los que viven en el intestino humano.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Chen, L., Yuan, L.","url":"https://www.biorxiv.org/content/10.64898/2026.10.24.761521v1?rss=1","imagen":"/hoy/portada/b9c6bc1c6b5422fd","tema":"ciencia","subtemas":["fagos","microbioma intestinal","virus","bacterias","genómica"],"entidades":["bacteriófagos","intestino humano","sortasa B"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-24T00:00:00.000Z","indexTs":"2026-10-25T10:38:14.778Z","hash":"a082cae8cf60da48bd908e628442cba8cd73012019b6b5611a62e73ae572dc17","tsa":{"time":"Oct 25 10:38:57 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Los fagos son virus que atacan bacterias, y los más grandes tienen decenas de proteínas que no se conocían bien. Hallaron una enzima, la sortasa B, que podría ayudar al virus a mostrar sus piezas sobre la superficie de la bacteria, algo que puede influir en cómo esa comunidad microbiana se comporta. El intestino de cada persona tiene miles de millones de bacterias, y estos virus son parte de ese equilibrio que cuesta mucho entender. Por ahora es una descripción de genomas, sin pruebas directas sobre salud.","quienFirma":"bioRxiv (preprint; autoría institucional no especificada en la fuente)","confianza":"preprint","consulta":null},"sello":{"hash":"a082cae8cf60da48bd908e628442cba8cd73012019b6b5611a62e73ae572dc17","sello":"f94fb269b824974a446cbf69077b9e22cff6bd064e6b7634ed1c0fb54a08e571","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6583123,"aleatorio":"01c23492917c8158ecd02d4ec7474f29dfb1b980670058951d0f80253dd2e82e","tiempo":"2026-10-25T10:38:30.000Z"},"nist":{"cadena":2,"pulso":1998755,"salida":"28775467E3830FECDCFFFCC12B583FF9E2CBEB95CB2305D52513ECFCE30159A86B42E261262E014B6D2C88558EBC490324F16DEE4150CE176C9AF14BC0C34477","tiempo":"2026-10-25T10:38:00.000Z"},"noAntes":"2026-10-25T10:38:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 25 10:38:57 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Large-genome phages encode diverse proteins associated with host cell envelope functions","descripcion":"Huge phages (or jumbo phages, >200 kilobases) encode extensive protein repertoires, yet their functional diversity and potential roles in host physiology remain poorly understood. Using protein structure-based analyses of dominant protein families across 7,187 non-redundant genomes of huge phages, we uncovered pronounced phylogenetic and habitat-associated diversification. Notably, we identified diverse proteins associated with bacterial cell envelope functions, particularly in human gut-associated huge phages. These included previously unreported phage-encoded sortase B, whose putative substrates contain signal peptides and cell-wall sorting signals, suggesting a potential route for display","pubDate":"2026-10-24","url":"https://www.biorxiv.org/content/10.64898/2026.10.24.761521v1?rss=1"},"indexado":"2026-10-25T10:38:14.778Z"}}