{"ok":true,"nota":{"id":"b2ae22f9f4779324","slug":"la-radioterapia-y-ciertos-tipos-de-cancer-de-mama-alteran-como-los-hue-b2ae22","titulo":"La radioterapia y ciertos tipos de cáncer de mama alteran cómo los huesos perciben el movimiento y se regenera","resumen":"Investigadores crearon un modelo tridimensional de osteocitos, las células que regulan el hueso, y lo expusieron a medios de cultivo de distintos subtipos de cáncer de mama, algunos tratados con radiación. Observaron que las alteraciones en la respuesta mecánica dependían del subtipo tumoral y del tratamiento.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Salcido-Alcantar, A., Bowman, C., Goldman, E., Briggs, E. N., Bierschenk, A. M., Rami, T. K., Thompson, W. R., Lynch, M.","url":"https://www.biorxiv.org/content/10.64898/2026.10.22.760275v1?rss=1","imagen":"/hoy/portada/b2ae22f9f4779324","tema":"salud","subtemas":["metastasis osea","cancer de mama","radioterapia","osteocitos","rehabilitacion osea"],"entidades":[],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-23T00:00:00.000Z","indexTs":"2026-10-23T22:31:31.922Z","hash":"740ef151e31c5a661de915304184e02f14a0391414b7fa02fdbd6d43ed9b0bf4","tsa":{"time":"Oct 23 22:31:53 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Las metástasis en el hueso debilitan la estructura ósea, y las pacientes suelen recibir radioterapia justo en esas zonas. Este trabajo sugiere que el tipo de tumor y el tratamiento modifican cómo el hueso responde al esfuerzo físico, algo que influye en la recuperación. Para una mujer en tratamiento en Mendoza o en Tucumán, eso podría traducirse en pensar la rehabilitación ósea de otra manera. Es un estudio en células cultivadas, así que todavía está lejos de la práctica clínica.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"740ef151e31c5a661de915304184e02f14a0391414b7fa02fdbd6d43ed9b0bf4","sello":"32e042d2e869ebc1148fc6f493e507e17040a33ecbb1695e30335b51dd28968d","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6578789,"aleatorio":"e3f8107d9895815bfd4cf7c8c0c58e563c54c18a406b9fd9519633dee417b54a","tiempo":"2026-10-23T22:31:30.000Z"},"nist":{"cadena":2,"pulso":1996588,"salida":"1AB33E4D4D8827C21F7F3557C5995F2A7803790AA889B11FBC3E8A1AAE593D51C4D6AF8D679624359D1D1868187DF78129DBF70BD659B8A94EB4847855F1EB6E","tiempo":"2026-10-23T22:31:00.000Z"},"noAntes":"2026-10-23T22:31:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 23 22:31:53 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Novel 3D Mature Osteocyte Perfusion Platform Reveals Subtype-Dependent and Radiation-Sensitive Disruption of Mechanotransduction by Breast Cancer Secretomes","descripcion":"Osteocytes (OCys) coordinate bone remodeling by transducing mechanical signals into anabolic cues, primarily through suppressing sclerostin and RANKL. In breast cancer (BCa) bone metastasis, mechanical loading fails to restore lost bone, pointing to tumor-induced OCy mechanosensory dysfunction. Here, we investigate how BCa molecular subtype heterogeneity and frontline therapies like radiation influence OCy mechanobiology. We leveraged a 3D mineralized scaffold paired with a forced perfusion bioreactor to establish a physiologically relevant model of mature, dendrite-bearing OCys. After optimizing perfusion parameters, 3D mature OCys were exposed to conditioned media (CM) from estrogen recept","pubDate":"2026-10-23","url":"https://www.biorxiv.org/content/10.64898/2026.10.22.760275v1?rss=1"},"indexado":"2026-10-23T22:31:31.922Z"}}