{"ok":true,"nota":{"id":"adc753be3600f824","slug":"un-compuesto-que-sube-el-camp-podria-apagar-la-respuesta-de-celulas-de-adc753","titulo":"Un compuesto que sube el cAMP podría apagar la respuesta de células de la nariz ligadas a pólipos","resumen":"Investigadores midieron en células de la nariz de ratones y de personas con pólipos nasales cómo responden al calcio y al cAMP. Probaron si activar la vía del cAMP podía bajar esas respuestas inflamatorias.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Polen, K., Kuek, L. E., Ma, Z., Adappa, N. D., Palmer, J. N., Carey, R. M., Lee, R. J.","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760783v1?rss=1","imagen":"/hoy/portada/adc753be3600f824","tema":"salud","subtemas":["pólipos nasales","rinosinusitis cronica","inflamacion","celulas epiteliales","señalizacion celular"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-25T00:00:00.000Z","indexTs":"2026-10-25T18:18:47.215Z","hash":"dbe9f8eedb2db1db0ad62a7ead74e72b8c7977634cf75414af5a525de6de7ff1","tsa":{"time":"Oct 25 18:19:08 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Los pólipos nasales crónicos son una inflamación que muchas personas padecen durante años, a veces operándose varias veces. Este estudio muestra que una vía química de las células puede usarse para calmar una de sus señales de alarma. Para quien tiene congestión constante, eso sugiere que existen blancos nuevos para fármacos futuros. Todavía se trabaja con células aisladas, así que el camino a un tratamiento es largo.","quienFirma":"bioRxiv (preprint)","confianza":"preprint","consulta":null},"sello":{"hash":"dbe9f8eedb2db1db0ad62a7ead74e72b8c7977634cf75414af5a525de6de7ff1","sello":"e872a6339883a05066edd10b15a638ecfc6ad8cba30693c0bcf2417a1956b2bd","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6584043,"aleatorio":"b5fd9bd83b3a4f54b7160d99b2be7ebb03f3a6d13c9fc67038a3cfb58d7a0c14","tiempo":"2026-10-25T18:18:30.000Z"},"nist":{"cadena":2,"pulso":1999215,"salida":"35343A11C1A43B552037A87872C3BBBA5198EE4A0D8BA56CDD0700BC2D12F3BC90BF7CBD775200EDD1DE14863960E13B9824460EE0F61C350371913ECEB95264","tiempo":"2026-10-25T18:18:00.000Z"},"noAntes":"2026-10-25T18:18:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 25 18:19:08 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Targeting cyclic-AMP/phosphodiesterase signaling to quiet nasal tuft cell calcium responses","descripcion":"Background: Airway tuft cells, also called solitary chemosensory cells, are enriched in nasal polyps and are likely the main epithelial source of interleukin-25 (IL-25) in chronic rhinosinusitis with nasal polyps (CRSwNP). Tuft cells are activated through G protein-coupled receptors (GPCRs) that signal through Ca2+. These receptors may also lower cyclic AMP (cAMP), but whether the cAMP pathway can be used to suppress tuft cell responses is unknown. Methods: Ca2+ and cAMP were measured by live cell imaging in isolated Trpm5-GFP mouse nasal tuft cells, and Ca2+ responses were measured in primary human nasal epithelial air-liquid interface (ALI) cultures from patients with CRSwNP. Defensin and ","pubDate":"2026-10-25","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760783v1?rss=1"},"indexado":"2026-10-25T18:18:47.215Z"}}