{"ok":true,"nota":{"id":"a9223c1088e6f3a6","slug":"un-estudio-con-mas-de-50-000-personas-encontro-nuevos-genes-que-influy-a9223c","titulo":"Un estudio con más de 50.000 personas encontró nuevos genes que influyen en la edad de inicio del Parkinson","resumen":"Un análisis genético combinó datos de más de 50.000 personas con Parkinson de origen europeo. Buscaron variantes genéticas asociadas a la edad en que aparecen los primeros síntomas.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"The Global Parkinson's Genetics Program (GP2),, Voss, E.","url":"https://www.medrxiv.org/content/10.64898/2026.10.20.26363947v1?rss=1","imagen":"/hoy/portada/a9223c1088e6f3a6","tema":"salud","subtemas":["parkinson","genetica","edad de inicio","enfermedades neurologicas","estudios de asociacion genomica"],"entidades":["UK Biobank","Global Parkinson's Genetics Program","SNCA","TMEM175","BST1"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T22:54:28.111Z","hash":"ac7dfe35469ad6bc8b0f62298058c11edc48c4b11f3643759cf29b3143f72061","tsa":{"time":"Oct 22 22:55:03 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"El Parkinson suele aparecer en personas mayores, pero en algunas empieza mucho antes, y hasta ahora se sabía poco de por qué. Este trabajo amplía el mapa de genes que modifican ese momento de inicio, lo que puede ayudar a entender mejor la enfermedad. Para una familia argentina con antecedentes, estos hallazgos todavía no cambian diagnósticos, pero orientan la búsqueda de tratamientos que retrasen los síntomas. El dato más valioso es que el estudio incluye poblaciones diversas, aunque la mayoría de los participantes sean de ascendencia europea.","quienFirma":"Global Parkinson's Genetics Program (GP2), International Parkinson's Disease Genomics Consortium e IPDGC/UK Biobank (consorcio multinacional","confianza":"preprint","consulta":null},"sello":{"hash":"ac7dfe35469ad6bc8b0f62298058c11edc48c4b11f3643759cf29b3143f72061","sello":"6e2b7924a3b28eed0d8291ddde4141dbdb333755f05d0bbc829bc1c00903bde9","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575956,"aleatorio":"2a57a8658c1d539864cc4ae3efbab33cd3270e814e75bf7846346721462f12e7","tiempo":"2026-10-22T22:55:00.000Z"},"nist":{"cadena":2,"pulso":1995177,"salida":"44471E1C8A000FA428D45A5C480CB1AAB6429BD43B19D16210510F8146BBA7769584FA09251B999E8D0B2F0EEC2EEEC53219499677294EE43E94C8610586BE7D","tiempo":"2026-10-22T22:54:00.000Z"},"noAntes":"2026-10-22T22:55:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 22:55:03 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Genetic Modifiers of Age at Onset for Parkinson's Disease in European Populations","descripcion":"Introduction Genetic variation contributes substantially to Parkinson's disease (PD) risk, but its role in modifying age at onset (AAO) is less well understood. Prior genome-wide association studies (GWAS) have identified AAO-associated signals at SNCA, TMEM175, and BST1, yet the majority of genetic contributors to AAO remain unknown. Objective To identify genetic determinants of PD AAO in the largest and most diverse European-ancestry cohort to date. Methods We conducted a GWAS meta-analysis of AAO in 50,859 individuals with PD, combining data from the Global Parkinson's Genetics Program (GP2), the International Parkinson's Disease Genomics Consortium (IPDGC), the UK Biobank (UKB), the Fox ","pubDate":"2026-10-22","url":"https://www.medrxiv.org/content/10.64898/2026.10.20.26363947v1?rss=1"},"indexado":"2026-10-22T22:54:28.111Z"}}