{"ok":true,"nota":{"id":"a22c94c90c81f8cb","slug":"en-mujeres-con-dolor-de-pecho-sin-obstruccion-en-las-arterias-los-neut-a22c94","titulo":"En mujeres con dolor de pecho sin obstrucción en las arterias, los neutrófilos inflamados aparecen como posibl","resumen":"Estudiaron sangre de 123 pacientes, en su mayoría mujeres, que tenían dolor de pecho pero arterias del corazón sin bloqueos grandes. Analizaron glóbulos blancos y su activación, y las células de los vasos coronarios.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"de Jong, E. A. M., Kapteijn, D., Daniels, M., Zweers, B., Peeters, D. A. M., Vrisekoop, N., Civelek, M., Haitjema, S., M","url":"https://www.medrxiv.org/content/10.64898/2026.10.30.26366961v1?rss=1","imagen":"/hoy/portada/a22c94c90c81f8cb","tema":"salud","subtemas":["cardiologia","dolor de pecho","salud de la mujer","inflamacion","neutrofilos"],"entidades":["medRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-11-02T00:00:00.000Z","indexTs":"2026-11-03T03:04:05.727Z","hash":"97bd7c4ae447b28a42c80a21ca87018d8b14b6f67aeeb4b69a2c8a6412c69557","tsa":{"time":"Nov  3 03:04:36 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Muchas mujeres con dolor de pecho reciben el diagnóstico de que sus arterias están bien y que no pasa nada, cuando en realidad los vasos más chicos del corazón pueden estar fallando. Este trabajo sugiere que una inflamación específica en la sangre podría explicarlo, lo que abre la puerta a diagnósticos más precisos. Todavía es un estudio transversal, con muestras chicas para algunos análisis, y falta confirmar que estos hallazgos sirvan para tratar a las pacientes.","quienFirma":"Institución no identificada en el resumen (preprint de medRxiv)","confianza":"preprint","consulta":null},"sello":{"hash":"97bd7c4ae447b28a42c80a21ca87018d8b14b6f67aeeb4b69a2c8a6412c69557","sello":"359ce64bb4f3285b4dd6625b617126f5fe020be271b08821cadbc9a60bc7e7f4","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6608134,"aleatorio":"3dab0d66c2c604dc92599227d91768428173493929465ddbdfa2591b205df8a4","tiempo":"2026-11-03T03:04:00.000Z"},"nist":{"cadena":2,"pulso":2011001,"salida":"B9ED3A0AAC8517006F07931DDB6E648454B7BCB1E6BFC680C866AD0654662ED7088F13877C8232BDDBCBBDFE3ACD00084FCE88FBDD4E982A20D9A58A5A491743","tiempo":"2026-11-03T03:03:00.000Z"},"noAntes":"2026-11-03T03:04:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Nov  3 03:04:36 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Interferon-activated neutrophils characterize coronary microvascular dysfunction in women with ANOCA","descripcion":"Background | Coronary microvascular dysfunction (CMD) is a common cause of ischemic symptoms in patients with angina and non-obstructive coronary arteries (ANOCA), predominantly women. Neutrophils may contribute to CMD via vascular inflammation and endothelial injury. We therefore investigated neutrophils and coronary endothelial cells in women with ANOCA. Methods | In this cross-sectional study, we collected blood samples from ANOCA patients (n=123, 84% women) undergoing coronary function testing. Complete blood counts (CELL-DYN, n=123) and neutrophil activation (AQUIOS, n=76) were assessed. Isolated neutrophils were profiled using single-cell RNA-seq (n=11). Guidewire-derived coronary endo","pubDate":"2026-11-02","url":"https://www.medrxiv.org/content/10.64898/2026.10.30.26366961v1?rss=1"},"indexado":"2026-11-03T03:04:05.727Z"}}