{"ok":true,"nota":{"id":"a18e5876d7e7327b","slug":"hallan-en-el-corazon-de-ninos-con-kawasaki-una-proteina-que-podria-ser-a18e58","titulo":"Hallan en el corazón de niños con Kawasaki una proteína que podría ser blanco de nuevos tratamientos","resumen":"Analizaron muestras de arterias coronarias de chicos que murieron con Kawasaki y mapearon dónde y cómo se concentra la inflamación. Encontraron que una proteína del sistema inmune, STING, aparece activa en esas zonas.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Ross, B. L., Atici, A. E., Lee, Y., Ngai, P., Schahrer, E., Lane, M. E., Fishbein, M. F., Yokouchi, Y., Takahashi, K., A","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.757759v1?rss=1","imagen":"/hoy/portada/a18e5876d7e7327b","tema":"salud","subtemas":["kawasaki","enfermedades cardíacas infantiles","inflamación","sistema inmune","investigación médica"],"entidades":["STING","enfermedad de Kawasaki"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-23T00:43:59.943Z","hash":"b30f72693db60edb8c589f077340f2c549f950ef71f982bb3e89406f9585626d","tsa":{"time":"Oct 23 00:44:44 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"La enfermedad de Kawasaki es la principal causa de problemas cardíacos adquiridos en chicos, y hoy los tratamientos no siempre alcanzan. Haber identificado dónde se organiza la inflamación dentro de la arteria ayuda a entender por qué se destruye la pared del vaso. Para una familia de acá, esto abre la posibilidad de que en algunos años existan medicamentos más específicos, aunque todavía falta mucho camino hasta llegar a un tratamiento probado. El trabajo se hizo con pocas muestras de autopsia, algo que obliga a confirmar los resultados en otros estudios.","quienFirma":"Estudio con muestras de pacientes con Kawasaki (institución principal no especificada en el texto)","confianza":"preprint","consulta":null},"sello":{"hash":"b30f72693db60edb8c589f077340f2c549f950ef71f982bb3e89406f9585626d","sello":"59783e9fcce039ff703b984e4711bde04ed0ac2a050eab00290ee8d5bf5d9321","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6576175,"aleatorio":"daeeb50ec9f7bca881613780dde9f04ee72a757e827db72aa67649836704893c","tiempo":"2026-10-23T00:44:30.000Z"},"nist":{"cadena":2,"pulso":1995287,"salida":"785B78E3E11077EB44F5EAC072C9D26D0DE3089D9E6EED05010A6176EC3F0436B59E7FA4CE1BBF17EA14BD9B8FE300D2C49C4FE98128B2B1F342A830C3D7920D","tiempo":"2026-10-23T00:44:00.000Z"},"noAntes":"2026-10-23T00:44:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 23 00:44:44 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Spatial profiling of Kawasaki disease cardiac inflammation identifies STING as a therapeutic target","descripcion":"The cellular subsets and in situ mechanisms underlying the development of coronary arteritis in Kawasaki disease (KD), the leading cause of acquired heart disease in children, remain poorly defined. We characterized the cellular composition and spatial organization of cardiac inflammation in autopsy coronary artery (CA) specimens from KD patients using 64-plex immunofluorescence. We identified spatially organized immune infiltrates of neutrophils, macrophages, and T cells associated with arterial wall destruction and remodeling, as well as disrupted stromal/muscle cell colocalization and diffuse myocardial inflammation. Spatial analysis also revealed expression of the innate immune sensor ST","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.757759v1?rss=1"},"indexado":"2026-10-23T00:43:59.943Z"}}