{"ok":true,"nota":{"id":"98df54412e095ae9","slug":"en-ratones-sin-una-molecula-clave-el-cerebro-cambia-de-tamano-y-de-est-98df54","titulo":"En ratones sin una molécula clave, el cerebro cambia de tamaño y de estructura en todo el órgano","resumen":"Estudiaron ratones genéticamente modificados que no producen una molécula grasa necesaria para el desarrollo cerebral. Con resonancia magnética de alta resolución y análisis de genes, compararon su cerebro con el de ratones normales.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Ilic, K., Kim, E., Mlinac-Jerkovic, K., Simmons, C., Puljko, B., Balog, M., Heffer, M., Cash, D., Rosenzweig, I., Kalanj","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759717v1?rss=1","imagen":"/hoy/portada/98df54412e095ae9","tema":"ciencia","subtemas":["neurociencia","ratones modificados","resonancia magnetica","desarrollo cerebral","genetica"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T22:31:26.226Z","hash":"948094448db50281c8bbe0257f55f6d38f56b336ee8ca2bee7146eb22ddef766","tsa":{"time":"Oct 22 22:32:10 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Como el hallazgo es en animales, no permite sacar conclusiones directas sobre personas, pero muestra que una sola falla molecular puede verse en todo el cerebro. Para un lector de acá, sirve para entender que el desarrollo del cerebro depende de piezas muy chicas que todavía se están mapeando.","quienFirma":"Universidad no especificada en el resumen (preprint de bioRxiv)","confianza":"preprint","consulta":null},"sello":{"hash":"948094448db50281c8bbe0257f55f6d38f56b336ee8ca2bee7146eb22ddef766","sello":"7a5154acb2972a6c18c53929d67d8d5af195cf4e9cc26fbba9bdd822115efdae","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575910,"aleatorio":"ad632c470ba8c968ea920b116993e6a501688139a43318de64f5a7ea72e81de2","tiempo":"2026-10-22T22:32:00.000Z"},"nist":{"cadena":2,"pulso":1995154,"salida":"A32727015042185E787530FED53F828C26131B55C644F3F364155FFBAB02AAA2930B78FFEE6913417A86FA34480E1F05FB9B4984B59D1A0E007BB8E6E3A95F8F","tiempo":"2026-10-22T22:31:00.000Z"},"noAntes":"2026-10-22T22:32:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 22:32:10 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Multiparametric MRI and imaging transcriptomics reveal brain-wide changes in GD3 synthase deficiency","descripcion":"Using an integrative imaging-transcriptomic approach that highlights the molecular complexity underlying neuroimaging phenotypes, we investigated a mouse model with disrupted ganglioside synthesis: the GD3 synthase-deficient mouse (St8sia1-null; GD3S KO). Gangliosides are membrane glycosphingolipids essential for brain development, neural plasticity and organisation of membrane lipid rafts. We performed high-resolution ex vivo magnetic resonance imaging (MRI) in male C57BL/6J mice aged 5-6 months (nine GD3 synthase-deficient and eight wild-type mice) to assess differences in brain structure, relaxation and diffusion properties. Total brain volume was larger in GD3S KO mice than in wild-type ","pubDate":"2026-10-22","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759717v1?rss=1"},"indexado":"2026-10-22T22:31:26.226Z"}}