{"ok":true,"nota":{"id":"9519e5f3e1bb6fda","slug":"encontraron-genes-vinculados-a-los-casos-graves-de-covid-19-con-pistas-9519e5","titulo":"Encontraron genes vinculados a los casos graves de COVID-19, con pistas sobre cuáles son los responsables","resumen":"Investigadores analizaron cómo varían la actividad de ciertos genes según la gravedad de la enfermedad y en distintas etapas, durante la infección y la recuperación. Cruzaron esos datos con estudios genéticos de casos graves de COVID-19.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Chen, E., Gabernet, G., Corry, D. B., Kheradmand, F., Baden, L. R., Sekaly, R.-P., McComsey, G. A., Haddad, E. K., Cairn","url":"https://www.medrxiv.org/content/10.64898/2026.10.14.26365529v1?rss=1","imagen":"/hoy/portada/9519e5f3e1bb6fda","tema":"ciencia","subtemas":["covid-19","genética","gravedad de enfermedades","expresión génica","medicina genómica"],"entidades":["COVID-19"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-22T04:37:56.220Z","hash":"dc77cc1f198bb4775ea0fc8368204a524112bc7c36d6c76b1371e52e5ee2ea3f","tsa":{"time":"Oct 22 04:38:38 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Se sabía que la genética influye en quién termina internado con COVID-19, pero no estaba claro qué genes hacían la diferencia. Este trabajo identifica genes candidatos que cambian su actividad según la gravedad, lo que apunta a mecanismos concretos. Con esa información se pueden orientar futuros tratamientos y pruebas de riesgo. Por ahora son candidatos a confirmar, no respuestas definitivas, y los estudios de este tipo suelen tener muestras relativamente chicas.","quienFirma":"Institución no indicada en el resumen","confianza":"preprint","consulta":null},"sello":{"hash":"dc77cc1f198bb4775ea0fc8368204a524112bc7c36d6c76b1371e52e5ee2ea3f","sello":"584393cc5e7013d59bae3a3366300c314d7d9a8eae31e5c2d82d1e147b262be2","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6573763,"aleatorio":"ac1ab9766ef209323093f9521e7402b29370fa8f04af200361451518fae9c9b2","tiempo":"2026-10-22T04:38:30.000Z"},"nist":{"cadena":2,"pulso":1994087,"salida":"2CAE0B0247F8B2C1365D5848B4971A88B86F8096596AB659C9B46851CC37B71B43230BE62392778D57CA4D0DAE3440419DC67D4E27A84A89E3AA5B314736F2A3","tiempo":"2026-10-22T04:38:00.000Z"},"noAntes":"2026-10-22T04:38:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 04:38:38 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Severity-stratified, longitudinal cis-eQTL mapping enables high-sensitivity detection of candidate causal genes for critical COVID-19","descripcion":"Host genetic variation influences heterogeneity in infectious disease severity. Genome-wide association studies (GWAS) have identified 69 lead single nucleotide polymorphisms (SNPs) associated with critical COVID-19, but most lack known regulatory mechanisms. To date, the genetic cis-regulatory effects of critical COVID-19 GWAS lead SNPs have not been systematically characterized across acute illness and convalescent phases in a COVID-19 specific cohort. Here, performing severity-stratified, longitudinal cis-expression quantitative trait loci (cis-eQTL) mapping and colocalization with critical COVID-19 GWAS signals, we find that host cis-regulatory effects vary across clinical severity and d","pubDate":"2026-10-21","url":"https://www.medrxiv.org/content/10.64898/2026.10.14.26365529v1?rss=1"},"indexado":"2026-10-22T04:37:56.220Z"}}