{"ok":true,"nota":{"id":"8fbcba652b9b0dd3","slug":"la-tdp-43-aparece-mas-en-personas-que-tienen-alzheimer-y-empiezan-con--8fbcba","titulo":"La TDP-43 aparece más en personas que tienen Alzheimer y empiezan con síntomas a partir de los 65","resumen":"Estudiaron 196 cerebros de personas con Alzheimer confirmado en autopsia, con muchos casos de inicio temprano. Midieron la frecuencia de la TDP-43 y su relación con la memoria y el tamaño de zonas cerebrales.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Zhu, N., La Joie, R., Allen, I. E., Lin, M., Fisher, D. L., Soleimani-Meigooni, D. N., Rosen, H. J., Gorno-Tempini, M. L","url":"https://www.medrxiv.org/content/10.64898/2026.10.15.26365384v1?rss=1","imagen":"/hoy/portada/8fbcba652b9b0dd3","tema":"salud","subtemas":["alzheimer","demencia","tdp-43","neuropatologia","memoria"],"entidades":["enfermedad de Alzheimer","amígdala","hipocampo"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-20T00:00:00.000Z","indexTs":"2026-10-20T23:32:18.927Z","hash":"a90c08d94ca79f5cca228bdd203e924d9ab6181fc0e931892c3b0735ac3b2ea0","tsa":{"time":"Oct 20 23:33:04 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Una de cada tres personas con Alzheimer en este grupo también tenía la proteína TDP-43 en zonas de la memoria. Cuanto más tarde empezaban los síntomas, más frecuente era, y los casos con ella tenían peor memoria episódica. Para quien tiene un familiar con Alzheimer, esto puede explicar por qué algunos cuadros avanzan distinto de lo esperado. Como el estudio se hizo en autopsias y con un grupo seleccionado, no sirve todavía para diagnosticar a nadie en vida.","quienFirma":"medRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"a90c08d94ca79f5cca228bdd203e924d9ab6181fc0e931892c3b0735ac3b2ea0","sello":"483ebde92fc0bba765f49d997fcb8bfa74f99d826ceb43db29c5b7078ce697c2","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6570272,"aleatorio":"bda24f270320f1e2527293c15ec727a66bdf246506dc957c7c9b6bd88c84b428","tiempo":"2026-10-20T23:33:00.000Z"},"nist":{"cadena":2,"pulso":1992341,"salida":"FA817D353D94A91CF41B4C174AAAB25209FED37DED6709559D325A28B103253A89D243C5C71B384CB4111753AA993F97FAC5CFB1C3257FDFA18ADA31FEE94D9A","tiempo":"2026-10-20T23:32:00.000Z"},"noAntes":"2026-10-20T23:33:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 20 23:33:04 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Too early for LATE? Age at onset is associated with the clinical and neuroimaging expression of limbic-predominant age-related TDP-43 pathology in Alzheimer's disease","descripcion":"Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) frequently co-occurs with Alzheimer's disease (AD) pathology and has been studied mainly in older populations. We examined its frequency and expression in 196 individuals with autopsy-confirmed intermediate-to-high AD neuropathologic change, enriched for younger-onset cases, integrating neuropathology with antemortem clinical, cognitive and neuroimaging data. LATE-NC occurred in 31% overall and 19% of individuals with symptom onset [≤]65 years. Its frequency increased with older age at symptom onset, and its presence was associated with greater episodic memory impairment and smaller amygdala and hippocam","pubDate":"2026-10-20","url":"https://www.medrxiv.org/content/10.64898/2026.10.15.26365384v1?rss=1"},"indexado":"2026-10-20T23:32:18.927Z"}}