{"ok":true,"nota":{"id":"8f9351aa101eadcc","slug":"bajar-la-glucosa-en-cerdos-prematuros-con-sepsis-redujo-la-inflamacion-8f9351","titulo":"Bajar la glucosa en cerdos prematuros con sepsis redujo la inflamación general pero no la del corazón","resumen":"Investigadores probaron en lechones prematuros con infección grave dos niveles de glucosa en la alimentación. Con menos glucosa bajó la inflamación en todo el cuerpo, pero no en el corazón.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Baek, O., Klabunde, B., Mouhammad, E., Dougthy, R., Leifsson, P., Olsen, L., Goetze, J. P., Thymann, T., Nguyen, D. N.","url":"https://www.biorxiv.org/content/10.64898/2026.10.14.759031v1?rss=1","imagen":"/hoy/portada/8f9351aa101eadcc","tema":"salud","subtemas":["sepsis neonatal","prematuros","glucosa","inflamación","cardiología infantil"],"entidades":["lechones prematuros","Staphylococcus epidermidis"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-20T00:00:00.000Z","indexTs":"2026-10-20T17:30:28.766Z","hash":"2ba71ba6e8fc0cb9f3a292aaea567e96e8c8d8104a5e1c58bb69e649afd5198b","tsa":{"time":"Oct 20 17:31:39 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"En bebés prematuros con infecciones graves, el azúcar en sangre puede agravar la inflamación. Este estudio muestra que reducir la glucosa ayuda en lo general, aunque el corazón respondió distinto. Para una familia de acá con un bebé internado en neonatología, la lección es que ningún ajuste simple protege todo el organismo a la vez. Hay que tener en cuenta que el trabajo fue con cerdos, no con personas, y que todavía falta confirmarlo en humanos.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"2ba71ba6e8fc0cb9f3a292aaea567e96e8c8d8104a5e1c58bb69e649afd5198b","sello":"c107bf3f4d39c6877372f3c446c91c95d4890651b1120e8713151af81863a8ee","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6569549,"aleatorio":"40f90a7c24002ff2f2230484261fe0762689a5f23536372bd9ca78a1043380ae","tiempo":"2026-10-20T17:31:30.000Z"},"nist":{"cadena":2,"pulso":1991980,"salida":"69E07DFEE11EFF4D62E2205CD9F3F399D52FEF236584C85A7AE96BEA74AB3905C910288488E7107D6A6068B76293A18CD91AD3E13518452A6064E4922DB00D59","tiempo":"2026-10-20T17:31:00.000Z"},"noAntes":"2026-10-20T17:31:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 20 17:31:39 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Glucose restriction reduces systemic, but not cardiac, inflammation during neonatal sepsis in preterm pigs","descripcion":"Introduction: Preterm infants are highly susceptible to sepsis and hyperglycemia may exacerbate inflammation and worsen outcomes. We examined how glucose provision influences systemic and cardiac responses during neonatal sepsis in preterm pigs. Methods: Preterm piglets (90 % gestation) were infused with Staphylococcus epidermidis to induce sepsis. In Experiment 1, three ventilated and anesthetized piglets were continuously monitored for mean arterial pressure (MAP) and blood gases to characterize acute cardiovascular and metabolic deterioration. In Experiment 2, thirty-three piglets were randomized to standard (14 g/kg/day) or reduced (3.5 g/kg/day) glucose provision, with or without infect","pubDate":"2026-10-20","url":"https://www.biorxiv.org/content/10.64898/2026.10.14.759031v1?rss=1"},"indexado":"2026-10-20T17:30:28.766Z"}}