{"ok":true,"nota":{"id":"8ba1a3403b276417","slug":"un-indice-genetico-sobre-neurotransmisores-no-permitio-predecir-que-an-8ba1a3","titulo":"Un índice genético sobre neurotransmisores no permitió predecir qué antidepresivos funcionan mejor","resumen":"Se analizaron genes ligados a neurotransmisores en pacientes con depresión mayor que tomaron ISRS durante al menos cuatro semanas. El objetivo fue ver si estos puntajes genéticos anticipaban la respuesta al tratamiento en dos cohortes internacionales.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Sharew, N. T., Clark, S. R., Arolt, V., Brockmoller, J., Chen, C.-H., Domschke, K., Hall-Flavin, D. K., Illi, A., Kampma","url":"https://www.medrxiv.org/content/10.64898/2026.10.18.26365850v1?rss=1","imagen":"/hoy/portada/8ba1a3403b276417","tema":"salud","subtemas":["depresión","antidepresivos","genética","farmacogenómica","salud mental"],"entidades":["International SSRI Pharmacogenomics Consortium","Pharmacogenomics Research Network"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-21T16:39:55.345Z","hash":"f5062876f9cf7030ac93ffd8d27782b67a3e781d10c3940e0e67266b66e5f9b9","tsa":{"time":"Oct 21 16:40:53 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"motor","registro":"hallazgo","porQueImporta":"El dato concreto es que la asociación entre estos puntajes y la respuesta al tratamiento fue la que se buscaba evaluar, y el resultado va en la línea de que todavía no sirven para elegir un medicamento. Para una persona con depresión en Argentina, esto significa que la búsqueda de un tratamiento a medida sigue siendo un proceso de prueba y error. Conviene leer el resultado con cautela, porque el propio campo aún no tiene herramientas genéticas listas para la consulta diaria.","quienFirma":"medRxiv (preprint; consorcio ISPC y Pharmacogenomics Research Network)","confianza":"preprint","consulta":{"pregunta":"¿Confiarías en elegir un antidepresivo según tus genes?"}},"sello":{"hash":"f5062876f9cf7030ac93ffd8d27782b67a3e781d10c3940e0e67266b66e5f9b9","sello":"2f8278a8a4b3378b84c9a9b3ec78b80247e4ed8ae11f7db03da7940934ef3c48","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6572327,"aleatorio":"d83e967e4c34cdf1b7eff62e6ba3c2a80c045b63fe1850f9291b003cd2f10aa6","tiempo":"2026-10-21T16:40:30.000Z"},"nist":{"cadena":2,"pulso":1993369,"salida":"46902ECFB36399313FFB65B445E71293DBF949380A38ED8B222CF72E430037F81238506B220BC468F19AAF1083C6EF424CA492E1A3404D8F36DA9E790C7B253D","tiempo":"2026-10-21T16:40:00.000Z"},"noAntes":"2026-10-21T16:40:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 21 16:40:53 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Association of neurotransmitter-based polygenic scores with antidepressant treatment outcomes in patients with major depressive disorder","descripcion":"Biologically informed polygenic scores (PGSs) may help interpret genetic associations with treatment outcomes. Here, we computed neurotransmitter-based PGSs (NeuroPGSs) for patients with major depressive disorder (MDD) and assessed their association with SSRI treatment outcomes. By targeting genetic variants involved in key neurotransmission pathways, we developed PGSs for serotonergic (5228), gamma-aminobutyric acid (GABA, 4103), dopaminergic (7061), and glutamatergic (5690) variants. We leveraged data from two cohorts of patients who received SSRIs for at least 4 weeks: the International SSRI Pharmacogenomics Consortium (ISPC) and the Pharmacogenomics Research Network Antidepressants Medic","pubDate":"2026-10-21","url":"https://www.medrxiv.org/content/10.64898/2026.10.18.26365850v1?rss=1"},"indexado":"2026-10-21T16:39:55.345Z"}}