{"ok":true,"nota":{"id":"8920757d1de6d5d0","slug":"una-bacteria-del-estomago-usa-una-estructura-de-su-flagelo-para-aferra-892075","titulo":"Una bacteria del estómago usa una estructura de su flagelo para aferrarse a las paredes y formar colonias","resumen":"Investigadores estudiaron cómo la bacteria Helicobacter pylori se mueve y se pega a superficies. Identificaron una proteína que conecta la estructura del flagelo con el interior de la célula para controlar esas conductas.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Fong, J. N. C., Witt, C. D., Huang, E. H. L., Yue, J., Liu, X., Roujeinikova, A., Liu, J., Ottemann, K.","url":"https://www.biorxiv.org/content/10.64898/2026.10.23.761471v1?rss=1","imagen":"/hoy/portada/8920757d1de6d5d0","tema":"ciencia","subtemas":["helicobacter pylori","bacterias","gastritis","biofilm","microbiología"],"entidades":["Helicobacter pylori","FapA"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-24T00:00:00.000Z","indexTs":"2026-10-25T10:38:14.778Z","hash":"716d90fc618dee2a4f553de8716a2a5b2c34b170d24eed483d52712f9d87eb59","tsa":{"time":"Oct 25 10:38:57 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Al borrar la proteína FapA, las bacterias se movían más y formaban menos colonias y biofilms, es decir, películas pegadas que les permiten sobrevivir. Esto importa porque H. pylori es una de las causas más comunes de gastritis y úlceras en el mundo, y en Argentina muchísima gente la tiene sin saberlo. Entender cómo se pega y se organiza abre la puerta a tratamientos que no dependan solo de antibióticos. Es un trabajo de laboratorio, así que el camino hasta una terapia todavía es largo.","quienFirma":"bioRxiv (preprint; autoría institucional no especificada en la fuente)","confianza":"preprint","consulta":null},"sello":{"hash":"716d90fc618dee2a4f553de8716a2a5b2c34b170d24eed483d52712f9d87eb59","sello":"b7538f46798e0ccc6922b4b0f6f126b3660c9cd7ef00c05d0c7cea4df6f40935","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6583123,"aleatorio":"01c23492917c8158ecd02d4ec7474f29dfb1b980670058951d0f80253dd2e82e","tiempo":"2026-10-25T10:38:30.000Z"},"nist":{"cadena":2,"pulso":1998755,"salida":"28775467E3830FECDCFFFCC12B583FF9E2CBEB95CB2305D52513ECFCE30159A86B42E261262E014B6D2C88558EBC490324F16DEE4150CE176C9AF14BC0C34477","tiempo":"2026-10-25T10:38:00.000Z"},"noAntes":"2026-10-25T10:38:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 25 10:38:57 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"FapA extends the flagellar cage-dependent network into the cytoplasm to control surface-associated behaviors in Helicobacter pylori","descripcion":"Flagellar systems enable many host-associated bacteria to colonize successfully. One such pathogen is Helicobacter pylori, which assembles an elaborate, high-torque flagellar motor that has a wide C-ring, 18 stator complexes, and is surrounded by a cage that includes homologs of the type IV pilus proteins PilM, PilN, and PilO. PilMNO act to repress soft-agar migration while promoting cell aggregation, microcolony, and biofilm formation, but the pathway linking the flagellar cage to these behaviors is unknown. Here we identify FapA, a member of the flagellar assembly protein A (FapA) family, as a component of this pathway. Deletion of fapA increased soft-agar migration and reduced microcolony","pubDate":"2026-10-24","url":"https://www.biorxiv.org/content/10.64898/2026.10.23.761471v1?rss=1"},"indexado":"2026-10-25T10:38:14.778Z"}}