{"ok":true,"nota":{"id":"87c0707e5bcf26dd","slug":"una-vacuna-con-hongos-muertos-protege-mejor-contra-la-meningitis-cript-87c070","titulo":"Una vacuna con hongos muertos protege mejor contra la meningitis criptocócica que otra versión","resumen":"Investigadores compararon en ratones una preparación de Cryptococcus neoformans modificada genéticamente con la cepa original, ambas inactivadas por calor. La versión modificada dio mayor protección en distintas condiciones.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Xue, C., Zhang, Y., Wang, Y., Wang, K., Gan, L., Lemmer, A., Pawar, S., Rivera, A.","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760669v1?rss=1","imagen":"/hoy/portada/87c0707e5bcf26dd","tema":"salud","subtemas":["vacunas","hongos","meningitis","vih","enfermedades infecciosas"],"entidades":["Cryptococcus neoformans","ratones"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-26T00:00:00.000Z","indexTs":"2026-10-26T14:53:25.658Z","hash":"719e5f75a928cb87c46e09e8659b7604885f1a5f9d4ec5fdcbc7909693d56781","tsa":{"time":"Oct 26 14:54:02 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"La meningitis criptocócica mata sobre todo a personas con VIH sin tratamiento, y hoy no hay ninguna vacuna contra este hongo en uso clínico. Un candidato que funciona mejor en ratones acerca un poco una opción que podría salvar vidas en zonas donde el VIH sigue siendo un problema. Pero todavía faltan ensayos en humanos, y los resultados en animales no garantizan lo mismo en personas.","quienFirma":"Investigadores de universidades de EE.UU. (publicación en bioRxiv)","confianza":"preprint","consulta":null},"sello":{"hash":"719e5f75a928cb87c46e09e8659b7604885f1a5f9d4ec5fdcbc7909693d56781","sello":"fa27458fb702aea1c3b58a60fbfdf553431f553addb431b757eaaa952824d91a","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6586513,"aleatorio":"29252d64ae5579343d3b4c7195e7f25e20e7efda9f7d116c213bca78231653a8","tiempo":"2026-10-26T14:53:30.000Z"},"nist":{"cadena":2,"pulso":2000450,"salida":"EA784D98D5763B66F010C392D53318D62D88381D9414E0DC9F82D155C4472FF568C7FE97610A1FBF61DB527240CD9D1CBCAD8004F69E7935CD2BA4DAEF79B485","tiempo":"2026-10-26T14:53:00.000Z"},"noAntes":"2026-10-26T14:53:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 26 14:54:02 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Development of an HK-fbp1-based vaccine platform against Cryptococcus neoformans","descripcion":"Cryptococcal meningitis remains a leading cause of death among HIV/AIDS patients, and no antifungal vaccine is available in clinical use. We previously showed that mice immunized with a heat-killed preparation of Cryptococcus neoformans (Cn) fbp1{Delta} mutant (HK-fbp1) are protected against cryptococcosis and other invasive mycoses, suggesting that HK-fbp1 is an intriguing vaccine candidate for further study. Recent studies have reported that heat-killed wild type H99 (HK-H99) can also offer some protection in other vaccination models. Here we set out to decipher the differential protective capacity of HK-fbp1 versus HK-H99 across multiple conditions. We observed that HK-fbp1 confers superi","pubDate":"2026-10-26","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760669v1?rss=1"},"indexado":"2026-10-26T14:53:25.658Z"}}