{"ok":true,"nota":{"id":"856008ad3b11eeef","slug":"uno-de-cada-diez-trasplantados-de-medula-adultos-tuvo-una-complicacion-856008","titulo":"Uno de cada diez trasplantados de médula adultos tuvo una complicación hepática grave","resumen":"Un estudio español revisó 793 trasplantes de médula en adultos para ver con qué frecuencia aparece el síndrome de obstrucción sinusoidal del hígado, una complicación que bloquea los vasos del hígado. Analizaron los factores de riesgo y un índice de laboratorio que ayuda a anticipar el problema.","fuente":"zenodo","fuenteNombre":"Zenodo · Investigación abierta","color":"#1682d4","autor":"Pérez-Martínez A., Cabrero M., Montoro J.","url":"https://doi.org/10.1038/s41409-026-02980-4","imagen":"/hoy/portada/856008ad3b11eeef","tema":"salud","subtemas":["trasplante de médula","obstrucción sinusoidal del hígado","factores de riesgo","complicaciones hepáticas","pronóstico"],"entidades":["GETH-TC"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-19T06:50:07.000Z","indexTs":"2026-10-21T10:34:42.643Z","hash":"b07df75a3b245cf584bb7ce4d79c5526378c0ab6f916d68780d2e363dee165ea","tsa":{"time":"Oct 21 10:35:56 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"En el hospital, la complicación aparece en promedio a los 15 días del trasplante, y eso obliga a mirar el hígado de cerca en esa ventana. Los pacientes que la sufrieron tuvieron más de cinco veces más riesgo de morir por causas ligadas al trasplante. Un número que sirve para anticipar quién necesita más vigilancia.","quienFirma":"Grupo español de trasplante de médula y terapia celular (GETH-TC)","confianza":"revisado","consulta":null},"sello":{"hash":"b07df75a3b245cf584bb7ce4d79c5526378c0ab6f916d68780d2e363dee165ea","sello":"b0ec5b7d8dfcba5f5d9c98b690e4b8a78efaa3bc5ba88e26678856ac4d4666a0","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6571597,"aleatorio":"457f4f4cf22f0e6c2e9758e5b211ac56883c24c6e8c5e375baf6537d39797215","tiempo":"2026-10-21T10:35:30.000Z"},"nist":{"cadena":2,"pulso":1993004,"salida":"23161ED84C8333D8735666F0B82E202695897452E701B068B63EF76A2E59D22F1B819FE2CF27AC06B5894483118E32D36F4246E7C1D82B4789A57D7588B065D3","tiempo":"2026-10-21T10:35:00.000Z"},"noAntes":"2026-10-21T10:35:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 21 10:35:56 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Incidence, clinical risk factors, and biomarkers of SOS/VOD following allogeneic HSCT in adults. A real-life study by the Spanish group of HSCT and cell therapy (GETH-TC).","descripcion":"Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) may occur after allo-HSCT. This retrospective study of 793 allo-HSCT performed in adult patients analyzes the impact of clinical risk factors and the EASIX score on the incidence and outcomes of SOS/VOD using Real-World data (GETH-TC registry). Severity and clinical risk factors were defined according to the EBMT-2023 criteria. The EASIX score was calculated at three time points after allo-HSCT (EASIX-day 0, d + 7, d + 14). SOS/VOD developed in 79 patients (10%), at a median time of 15 days. The cumulative incidence of SOS/VOD at 30 and 90 days post-HSCT was 8.58% and 9.97%, respectively. Defibrotide was used in 44 patients (56%) who developed SOS/VOD. Patients with SOS/VOD experienced an increased risk of NRM (HR 5.56; p < 0.001). Multivariate analysis confirmed the prognostic value for SOS/VOD incidence of second ","pubDate":"2026-10-19T06:50:07Z","url":"https://doi.org/10.1038/s41409-026-02980-4"},"indexado":"2026-10-21T10:34:42.643Z"}}