{"ok":true,"nota":{"id":"81579a56fbda4e30","slug":"en-moscas-cuando-las-celulas-de-sosten-se-danan-primero-la-enfermedad--81579a","titulo":"En moscas, cuando las células de sostén se dañan primero, la enfermedad de Huntington avanza más lento","resumen":"Con moscas de la fruta modificadas genéticamente, investigadores compararon cómo progresa la enfermedad de Huntington según afecte a las células gliales de sostén o directamente a las neuronas.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Chatterjee, D., Gupta, J., Yadav, M., Mittal, P., Agrawal, N., Shrivastava, A.","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760655v1?rss=1","imagen":"/hoy/portada/81579a56fbda4e30","tema":"salud","subtemas":["enfermedad de huntington","neurodegeneración","células gliales","modelos animales"],"entidades":["Drosophila melanogaster"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-24T00:00:00.000Z","indexTs":"2026-10-24T13:11:28.041Z","hash":"dc54bbc90566528894a67613d1cb9adf0e02cdc4458050bbe781d626da4bed88","tsa":{"time":"Oct 24 13:11:52 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Cuando el daño empieza en las células de sostén, los síntomas motores aparecen más tarde y la muerte también se demora, en comparación con el daño directo a las neuronas. Esto sugiere que las células de apoyo tienen un papel importante en cómo avanza la enfermedad. Para familias argentinas que conviven con Huntington, la idea de que hay más de un blanco posible para frenarla es relevante. Es un estudio en moscas, así que todavía falta llevarlo a humanos.","quienFirma":"bioRxiv · preprints","confianza":"preprint","consulta":null},"sello":{"hash":"dc54bbc90566528894a67613d1cb9adf0e02cdc4458050bbe781d626da4bed88","sello":"567e82a7877483abb40f7c3b982ac1030b4f19193132e3cd8bb2b2f49551f304","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6580549,"aleatorio":"7911ede6e40eb43c8d52a5aa70989c9e983bf6b4e3e546038bdf2fb3f7963d94","tiempo":"2026-10-24T13:11:30.000Z"},"nist":{"cadena":2,"pulso":1997468,"salida":"17E8B17C027FF6563CB9C523DB47FDE314546641306A50EB72EBE3F0C682F5AD47E98E06F21F7AF2C586B0ABC09F74B248595311CFF4E4AD942361BBAD0151C4","tiempo":"2026-10-24T13:11:00.000Z"},"noAntes":"2026-10-24T13:11:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 24 13:11:52 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Glial Mutant Huntingtin Expression Initiates a Progressive Pathological Cascade Toward Neuronal Involvement in Drosophila","descripcion":"The mechanisms of involvement of glial cells in the progression of Huntingtons disease remain sparingly elucidated. Using the Drosophila melanogaster model, we investigated the temporal course of the disease pathogenesis induced by pan-glial expression of HTTex1pQ93 in comparison to the temporal course of pathology induced by pan-neuronal expression. Our behavioural data were supported by quantitative confocal microscopy, quantification of aggregate formation and its morphometry, Manders M2 colocalization index, and correlative holotomography. Expression of mHTT in glial cells led to developmental defects and subsequent delayed onset of motor dysfunction and death with increasing amounts of ","pubDate":"2026-10-24","url":"https://www.biorxiv.org/content/10.64898/2026.10.21.760655v1?rss=1"},"indexado":"2026-10-24T13:11:28.041Z"}}