{"ok":true,"nota":{"id":"7eb72033603a4c79","slug":"una-sola-exposicion-a-silice-cristalina-dana-en-silencio-pulmon-arteri-7eb720","titulo":"Una sola exposición a sílice cristalina daña en silencio pulmón, arterias y corazón en ratones","resumen":"Ratones expuestos una única vez a sílice cristalina mostraron alteraciones sutiles en pulmón, arteria pulmonar y ventrículo derecho antes de cualquier síntoma visible. Se compararon machos y hembras y se analizaron también programas moleculares.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Gwin, M. S., Di Palo, J., Fung, A. A., Choi, R., Gueldner, P. H., Regan, A., Nagamalla, A., Syed, A. A., Sandow, T., Sun","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760460v1?rss=1","imagen":"/hoy/portada/7eb72033603a4c79","tema":"salud","subtemas":["sílice cristalina","enfermedad pulmonar","salud cardiovascular","exposición laboral","riesgo ocupacional"],"entidades":["sílice cristalina","ratones"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-24T00:00:00.000Z","indexTs":"2026-10-24T16:02:27.653Z","hash":"e17f11929ff7b8b253df107dd128e4c67490fffdfbfb0871cf321718dd86c088","tsa":{"time":"Oct 24 16:02:51 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"La sílice cristalina está presente en la construcción, la minería y el trabajo con piedra, y en Argentina afecta a miles de trabajadores. El estudio sugiere que el daño cardiopulmonar puede empezar mucho antes de que aparezca la falta de aire, lo que vuelve importante controlar la exposición desde el inicio. El trabajo es preliminar, hecho en animales y aún sin revisión por pares, así que sus conclusiones deben tomarse con cautela. Aun así, plantea una pregunta incómoda: cuántos años de daño silencioso acumula un trabajador antes de que alguien lo mida.","quienFirma":"bioRxiv (institución principal no indicada)","confianza":"preprint","consulta":null},"sello":{"hash":"e17f11929ff7b8b253df107dd128e4c67490fffdfbfb0871cf321718dd86c088","sello":"f83ffa918f201674c54c2a101aed10451238557168358abc6642ab8e8e9fdcf9","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6580890,"aleatorio":"10b843f815aa592890ab5708bbe3e30aa649ae4903f4b04ddbaea43ecdff5368","tiempo":"2026-10-24T16:02:00.000Z"},"nist":{"cadena":2,"pulso":1997638,"salida":"DC8390B2FC8E41804FBC87410481560B6FD9A3106ED549AAA1ED207C199FF576B4E5003E4E7503F6C74985AB90AFA7E81F35A2A0C13763958FE82A55C83DB3FA","tiempo":"2026-10-24T16:01:00.000Z"},"noAntes":"2026-10-24T16:02:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 24 16:02:51 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Crystalline silica exposure causes latent biomechanical abnormalities along the cardiopulmonary axis","descripcion":"Rationale Crystalline silica exposure is a major global health burden linked to chronic lung disease and cardiopulmonary morbidity, but early lung-vascular-cardiac abnormalities preceding overt functional decline are poorly defined. Objectives To determine whether a single crystalline silica exposure produces subclinical abnormalities across the integrated axis of cardiopulmonary response (lung[->]pulmonary artery[->]right ventricle) and identify associated sex-dependent physiologic patterns and molecular programs. Methods Male and female mice received a single endotracheal instillation of crystalline silica or vehicle (saline). At 28 days, assessments included voluntary wheel running, diffu","pubDate":"2026-10-24","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760460v1?rss=1"},"indexado":"2026-10-24T16:02:27.653Z"}}