{"ok":true,"nota":{"id":"795f224ea27ee7c6","slug":"diferencias-en-el-cerebro-entre-depresion-y-bipolaridad-y-entre-hombre-795f22","titulo":"Diferencias en el cerebro entre depresión y bipolaridad, y entre hombres y mujeres","resumen":"Investigadores analizaron el tejido de la corteza prefrontal de personas con depresión, trastorno bipolar y sin diagnóstico, mirando qué genes se activan en cada zona. Compararon cómo cambian esos patrones según el diagnóstico y el sexo biológico.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Thompson, J. R., Oh, S., Maguire, S. E., Bach, S. V., Mulvey, B. J., Pertea, G., Abramson, M. R., Miller, R. A., Kwon, S","url":"https://www.biorxiv.org/content/10.64898/2026.10.22.761067v1?rss=1","imagen":"/hoy/portada/795f224ea27ee7c6","tema":"ciencia","subtemas":["salud mental","depresión","trastorno bipolar","neurociencia","diferencias por sexo"],"entidades":["bioRxiv","corteza prefrontal","trastorno depresivo mayor","trastorno bipolar"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-24T00:00:00.000Z","indexTs":"2026-10-24T13:11:28.041Z","hash":"24e4f5fc8b8bf4a7edc4fea5d1dc38bfdfb810a113d01e1a9f641987a8d28bd6","tsa":{"time":"Oct 24 13:12:02 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"El estudio muestra que la depresión y el bipolar comparten algunas huellas moleculares en el cerebro, pero también tienen firmas propias, y que el sexo biológico modifica esas diferencias. Para quien convive con alguno de estos diagnósticos, esto apunta a que un mismo síntoma puede tener causas distintas según la persona. Es un paso para dejar de tratar estos trastornos como un bloque único. El trabajo es un preprint, todavía sin revisión de pares, y analiza un número limitado de cerebros.","quienFirma":"Preprint en bioRxiv (instituciones de investigación en neurociencia)","confianza":"preprint","consulta":null},"sello":{"hash":"24e4f5fc8b8bf4a7edc4fea5d1dc38bfdfb810a113d01e1a9f641987a8d28bd6","sello":"2742d8b6e4d69b9d4fa32120759d6a1571ebc73abb9953b1043b7f759581efbd","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6580549,"aleatorio":"7911ede6e40eb43c8d52a5aa70989c9e983bf6b4e3e546038bdf2fb3f7963d94","tiempo":"2026-10-24T13:11:30.000Z"},"nist":{"cadena":2,"pulso":1997468,"salida":"17E8B17C027FF6563CB9C523DB47FDE314546641306A50EB72EBE3F0C682F5AD47E98E06F21F7AF2C586B0ABC09F74B248595311CFF4E4AD942361BBAD0151C4","tiempo":"2026-10-24T13:11:00.000Z"},"noAntes":"2026-10-24T13:11:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 24 13:12:02 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Overlapping yet distinct spatiomolecular profiles across mood disorders and biological sex in the human prefrontal cortex","descripcion":"Major depressive disorder (MDD) and bipolar disorder (BD) exhibit both overlapping and distinct clinical features, including sex differences in prevalence and symptomatology, but how these similarities and differences are reflected at the molecular and cellular level in the human brain remains poorly understood. Here, we applied spatial transcriptomics to the human dorsolateral prefrontal cortex from individuals with MDD, BD, and neurotypical controls to resolve molecular programs associated with diagnosis and biological sex. Our analysis revealed sex- and diagnosis-specific differences across white matter, the neurovascular unit (NVU), and neuronal compartments. Within white matter, we iden","pubDate":"2026-10-24","url":"https://www.biorxiv.org/content/10.64898/2026.10.22.761067v1?rss=1"},"indexado":"2026-10-24T13:11:28.041Z"}}