{"ok":true,"nota":{"id":"758ff43b7ec0b82e","slug":"en-ratones-con-una-malformacion-cerebral-la-zona-danada-crece-con-el-t-758ff4","titulo":"En ratones con una malformación cerebral, la zona dañada crece con el tiempo","resumen":"Científicos siguieron durante semanas a ratones con una malformación cerebral parecida a la de algunos pacientes con epilepsia. Filmaron la actividad de las neuronas y registraron las descargas eléctricas antes y durante las crisis.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Rehorova, M., Rozlivkova, J. T., Populova, J., Prochazkova, N., Olson, C. V., Shariati, N., Kudlacek, J., Jiruska, P., N","url":"https://www.biorxiv.org/content/10.64898/2026.10.24.761526v1?rss=1","imagen":"/hoy/portada/758ff43b7ec0b82e","tema":"ciencia","subtemas":["epilepsia","malformaciones corticales","neurociencia","crisis epilepticas","modelos animales"],"entidades":["bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-25T00:00:00.000Z","indexTs":"2026-10-25T18:18:47.215Z","hash":"03101da101f96d19a09d6de6284c6481c116454e5b34aea1f4b0be598cda97b8","tsa":{"time":"Oct 25 18:19:08 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"La lesión que causa cierta epilepsia resistente a medicamentos no se queda quieta: en el modelo estudiado se expande con el tiempo. Además, las neuronas cercanas dejan de sumarse a la actividad previa a las descargas, lo que cambia la forma en que se piensa el inicio de una crisis. Para quien convive con una epilepsia así, esto significa que intervenir temprano podría pesar más de lo que se creía. Es un trabajo en animales y no permite todavía sacar conclusiones clínicas.","quienFirma":"bioRxiv (preprint)","confianza":"preprint","consulta":null},"sello":{"hash":"03101da101f96d19a09d6de6284c6481c116454e5b34aea1f4b0be598cda97b8","sello":"961897f6571bcc58f8a34fba033174caec1489e7b4a1c2fdeb73ecab6dc37070","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6584043,"aleatorio":"b5fd9bd83b3a4f54b7160d99b2be7ebb03f3a6d13c9fc67038a3cfb58d7a0c14","tiempo":"2026-10-25T18:18:30.000Z"},"nist":{"cadena":2,"pulso":1999215,"salida":"35343A11C1A43B552037A87872C3BBBA5198EE4A0D8BA56CDD0700BC2D12F3BC90BF7CBD775200EDD1DE14863960E13B9824460EE0F61C350371913ECEB95264","tiempo":"2026-10-25T18:18:00.000Z"},"noAntes":"2026-10-25T18:18:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 25 18:19:08 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Longitudinal Imaging in a Mouse Model of Focal Cortical Dysplasia Reveals Lesion Expansion and Loss of Pre-Discharge Neuronal Recruitment","descripcion":"ABSTRACT Objective: Focal cortical dysplasia type II (FCD II) is a leading cause of drug-resistant focal epilepsy, yet how its lesional circuits behave and change over time in vivo has not been directly observed. Methods: We used a mouse model of FCD II carrying the patient-derived gain-of-function mTORp.L2427P variant introduced by in utero electroporation. Through a chronic cranial window over the lesion, we performed repeated in vivo two-photon calcium imaging of identified dysmorphic neurons, pyramidal cells, and VIP interneurons at defined time points, combined with video-EEG monitoring, to determine seizure status and relate cellular activity to interictal discharges. Results: The lesi","pubDate":"2026-10-25","url":"https://www.biorxiv.org/content/10.64898/2026.10.24.761526v1?rss=1"},"indexado":"2026-10-25T18:18:47.215Z"}}