{"ok":true,"nota":{"id":"72e935c9522671d2","slug":"un-analisis-del-adn-de-tumores-infantiles-encontro-subgrupos-nuevos-de-72e935","titulo":"Un análisis del ADN de tumores infantiles encontró subgrupos nuevos de rabdomiosarcoma","resumen":"Analizaron los patrones de metilación del ADN en dos grandes grupos de tumores de rabdomiosarcoma, un cáncer de tejidos blandos en niños. Compararon esos patrones con la histología, las mutaciones y los datos clínicos de cada paciente.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Sun, W., Lopez-Nava, J., Shern, J. F., Rudzinski, E. R., Arnold, M. A., Surrey, L. F., Raju, M., Kakarla, A. R., Chatter","url":"https://www.medrxiv.org/content/10.64898/2026.10.22.26365442v1?rss=1","imagen":"/hoy/portada/72e935c9522671d2","tema":"ciencia","subtemas":["rabdomiosarcoma","cáncer infantil","metilación del adn","genética tumoral","clasificación de tumores"],"entidades":["medRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-22T00:00:00.000Z","indexTs":"2026-10-22T21:54:18.823Z","hash":"ea773784a02af21fe92ed5bafa13eb470a58f8d2ebc373965cf003b6fe664282","tsa":{"time":"Oct 22 21:55:35 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Hasta ahora este cáncer infantil se dividía sobre todo según una fusión genética, y el trabajo sugiere que hay subgrupos más finos con comportamientos distintos. Si esas diferencias se confirman, podrían orientar mejor qué tratamiento recibe cada chico. Para una familia de acá, la noticia es que la clasificación de los tumores sigue afinándose y que eso puede cambiar decisiones médicas concretas.","quienFirma":"medRxiv (preprint)","confianza":"preprint","consulta":null},"sello":{"hash":"ea773784a02af21fe92ed5bafa13eb470a58f8d2ebc373965cf003b6fe664282","sello":"6721287a2e2f48cffcb70391d9abb94c2bd1ab1f2c6a1021fa49b855447ca627","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6575837,"aleatorio":"63461f681b6ee92f4c36de6febc3c3c4fe7c3906de725dea83aeab9ec81b1467","tiempo":"2026-10-22T21:55:30.000Z"},"nist":{"cadena":2,"pulso":1995118,"salida":"F0E0C41C949133434038AD3665131BA50B8741AD6763A98DA9C9F98A82572C39F0270A26E31EB0E30B2F4719DE6ED82AA401EE3E9EB6515A5780BD147A7BE091","tiempo":"2026-10-22T21:55:00.000Z"},"noAntes":"2026-10-22T21:55:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 21:55:35 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"DNA methylation profiling reveals novel rhabdomyosarcoma subsets with distinct histologic, genetic and clinical properties","descripcion":"Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma, and is commonly divided into fusion-positive (FP) (predominantly PAX3::FOXO1 or PAX7::FOXO1) and fusion-negative (FN) subtypes. Based on our earlier finding of different DNA methylation patterns in the FP and FN subtypes, we hypothesized that there are methylation-defined subsets within the FP and FN subtypes that are associated with distinct clinical and biological differences. To explore this hypothesis, we examined the methylation profiles of two large independent cohorts of RMS tumors, and assessed histology, fusion status, mutations, copy number and clinical parameters in the subsets defined by this methylation ana","pubDate":"2026-10-22","url":"https://www.medrxiv.org/content/10.64898/2026.10.22.26365442v1?rss=1"},"indexado":"2026-10-22T21:54:18.823Z"}}