{"ok":true,"nota":{"id":"70a3dbc7d8f32f84","slug":"el-hipocampo-ayuda-a-que-el-dolor-se-modifique-segun-lo-que-uno-asocia-70a3db","titulo":"El hipocampo ayuda a que el dolor se modifique según lo que uno asocia, no solo con la imagen exacta","resumen":"Treinta y seis personas aprendieron a asociar dos categorías visuales con calor doloroso alto o bajo. Luego vieron estímulos nuevos de esas mismas categorías, con resonancia magnética funcional. Los análisis mostraron que el hipocampo media esa generalización del dolor.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Sutterlin-Guindon, D., Wager, T. D., Koban, L.","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759532v1?rss=1","imagen":"/hoy/portada/70a3dbc7d8f32f84","tema":"salud","subtemas":["dolor","neurociencia","hipocampo","aprendizaje asociativo","resonancia magnetica"],"entidades":["hipocampo","36 participantes"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-21T22:39:37.287Z","hash":"36712082ae9013b227b0182daefe7a61e3bfe1b6946a429508baa128e608557b","tsa":{"time":"Oct 21 22:40:36 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Lo que uno espera sentir puede cambiar cuánto duele algo, y esa expectativa se extiende a cosas parecidas por concepto y no solo por aspecto. Para alguien que vive con dolor crónico, esto explica por qué ciertos lugares, imágenes o palabras pueden empeorar o aliviar una molestia. El experimento fue en laboratorio, con pocos participantes y calor controlado, así que sus efectos en la vida real aún no están medidos.","quienFirma":"Institución no identificada en el texto disponible","confianza":"preprint","consulta":null},"sello":{"hash":"36712082ae9013b227b0182daefe7a61e3bfe1b6946a429508baa128e608557b","sello":"a0a7809366525cbf6b7382c75127a6e06fcc9a13278dfde894edccbd5c41e1a0","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6573046,"aleatorio":"f71b3db032f12c8ae2d90f38aa37ddc03a4bd072f8a3317f2962e831c62e695d","tiempo":"2026-10-21T22:40:00.000Z"},"nist":{"cadena":2,"pulso":1993728,"salida":"DBB029F00A75EEAA9AF69BB0B3207AD12D5A4EDD2136CB35D25CB332980962472F1AFBB0B247EB7DF6BE52045BC8A63F1D14E2719075ECD2BA39DE673005A0E1","tiempo":"2026-10-21T22:39:00.000Z"},"noAntes":"2026-10-21T22:40:00.000Z"},"verificacion":{"drand":true,"nist":"inaccesible"},"tsa":{"time":"Oct 21 22:40:36 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Hippocampus mediates conceptual generalization of pain modulation","descripcion":"Pain is strongly influenced by expectations and learning from previous experience, such as in classical conditioning. Conditioned responses and expectations can generalize to perceptually and conceptually related cues, but how generalization influences pain experience and the neurobiological processing of pain remains unclear. We used fMRI and multilevel mediation analyses to address this question. Thirty-six human participants first learned to associate two visual cues from distinct conceptual categories (e.g., animals vs. vehicles) with high or low levels of heat pain. In a subsequent phase, they were presented with novel cues (images, drawings, or words) not previously paired with pain, b","pubDate":"2026-10-21","url":"https://www.biorxiv.org/content/10.64898/2026.10.16.759532v1?rss=1"},"indexado":"2026-10-21T22:39:37.287Z"}}