{"ok":true,"nota":{"id":"6f00e5175cd25ddd","slug":"un-gen-de-las-celulas-t-es-clave-para-que-el-cuerpo-controle-a-un-para-6f00e5","titulo":"Un gen de las células T es clave para que el cuerpo controle a un parásito del gato","resumen":"Experimentos con ratones modificados para no tener el gen T-bet en sus linfocitos CD4 mostraron cómo responde el sistema inmune frente al Toxoplasma gondii. Analizaron la protección del sistema nervioso central durante la infección.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Woellner-Santos, D., Zadeii, K., DelVecchio, R., Somenzi, M., Lopez-Yglesias, A.","url":"https://www.biorxiv.org/content/10.64898/2026.10.15.759516v1?rss=1","imagen":"/hoy/portada/6f00e5175cd25ddd","tema":"salud","subtemas":["sistema inmune","toxoplasmosis","linfocitos t","infecciones"],"entidades":["bioRxiv","Toxoplasma gondii"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-22T04:37:56.220Z","hash":"c22312ae40ae10f4e9d4faa4db69d078482aa8beef34877090a412e7b5f753ba","tsa":{"time":"Oct 22 04:38:22 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Se pensaba que T-bet actuaba en todo el sistema inmune como un interruptor general, y este trabajo muestra que en las células T tiene un papel propio e importante. Para alguien de acá, el Toxoplasma es un parásito muy común, presente en muchas personas sin que lo noten, y entender qué frena su avance en el cerebro importa para la salud. Son resultados en ratones, así que no se pueden trasladar directamente a personas.","quienFirma":"bioRxiv (preprint de investigadores internacionales)","confianza":"preprint","consulta":null},"sello":{"hash":"c22312ae40ae10f4e9d4faa4db69d078482aa8beef34877090a412e7b5f753ba","sello":"dfbd18b3695938e465234f5379af9a4a077e953cc425368fbe0aa28935c63bef","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6573762,"aleatorio":"2bf3d68605c0cf93c7b24bcf7d4852029c1a8fd2dd29c3bf1b3b697bee72ee36","tiempo":"2026-10-22T04:38:00.000Z"},"nist":{"cadena":2,"pulso":1994086,"salida":"7C444532759162AF322A7FA62FB67EDB4DE6FC6E7A6186DDCB567613FCA6BF322E4D0A282AEEE85DC1460DE99BE46FB63B8A2617A10BE805A6618E195E0116AC","tiempo":"2026-10-22T04:37:00.000Z"},"noAntes":"2026-10-22T04:38:00.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 22 04:38:22 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"CD4+ T cell-intrinsic T-bet sustains protective CNS immunity and parasite control during Toxoplasma gondii infection","descripcion":"The transcription factor T-bet is widely regarded as the master regulator of type 1 immunity and is considered essential for host resistance to intracellular pathogens. Previous studies have demonstrated that global T-bet deficiency causes profound susceptibility to intracellular pathogens, including T. gondii. However, the specific cell-intrinsic requirement for T-bet within CD4+ T cells has remained unclear because T-bet regulates multiple innate and adaptive immune populations that contribute to protective immunity. Therefore, to define the cell-intrinsic role of T-bet in CD4+ T cells during infection, we utilized mice with conditional T-bet deletion in CD4+ T cells (CD4-Tbx21-/-) and fou","pubDate":"2026-10-21","url":"https://www.biorxiv.org/content/10.64898/2026.10.15.759516v1?rss=1"},"indexado":"2026-10-22T04:37:56.220Z"}}