{"ok":true,"nota":{"id":"6eb734c83d4266ad","slug":"una-enzima-dirigida-a-las-mitocondrias-ayuda-a-recuperar-pulmones-dana-6eb734","titulo":"Una enzima dirigida a las mitocondrias ayuda a recuperar pulmones dañados por cloro","resumen":"Investigadores usaron secuenciación de núcleos celulares individuales para estudiar cómo el cloro daña los pulmones de ratones. Evaluaron una proteína de fusión que repara el ADN mitocondrial después de la exposición. Mapearon los tipos celulares y estados de transición involucrados en la lesión y la reparación.","fuente":"biorxiv","fuenteNombre":"bioRxiv · preprints","color":"#be2628","autor":"Dubey, S., Crossman, D. K., Matalon, S.","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760415v1?rss=1","imagen":"/hoy/portada/6eb734c83d4266ad","tema":"salud","subtemas":["toxicología","lesión pulmonar","mitocondrias","gases tóxicos","investigación preclínica"],"entidades":["OGG1","bioRxiv"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-21T00:00:00.000Z","indexTs":"2026-10-21T16:39:55.345Z","hash":"2df03f9a4d588dd40f20fe57839b5e6794d056af2d753bf635a532883993779b","tsa":{"time":"Oct 21 16:40:53 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":0,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"El cloro es un gas industrial que puede causar lesiones pulmonares graves y no existe un tratamiento aprobado que actúe directamente sobre el daño. Este trabajo muestra qué células se afectan y cómo se comunican con el sistema inmune durante la lesión. Para alguien que vive cerca de una planta industrial o de rutas de transporte de sustancias químicas, la noticia es que hay caminos terapéuticos en estudio. Todavía se trata de investigación preclínica en animales.","quienFirma":"bioRxiv (preprint; grupo de investigación en toxicología pulmonar)","confianza":"preprint","consulta":null},"sello":{"hash":"2df03f9a4d588dd40f20fe57839b5e6794d056af2d753bf635a532883993779b","sello":"607b855e2f2a480f59473b148535a5de9dfab9a5166b24120e61955fee2b66fa","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6572327,"aleatorio":"d83e967e4c34cdf1b7eff62e6ba3c2a80c045b63fe1850f9291b003cd2f10aa6","tiempo":"2026-10-21T16:40:30.000Z"},"nist":{"cadena":2,"pulso":1993369,"salida":"46902ECFB36399313FFB65B445E71293DBF949380A38ED8B222CF72E430037F81238506B220BC468F19AAF1083C6EF424CA492E1A3404D8F36DA9E790C7B253D","tiempo":"2026-10-21T16:40:00.000Z"},"noAntes":"2026-10-21T16:40:30.000Z"},"verificacion":{"drand":true,"nist":true},"tsa":{"time":"Oct 21 16:40:53 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Mitochondria-Targeted OGG1 remodels Alveolar Epithelial Transitional States and Immune-Epithelial Communication after Chlorine Lung Injury","descripcion":"Chlorine (Cl2) inhalation causes acute epithelial and endothelial injury, pulmonary edema, inflammation, and impaired gas exchange, yet no approved therapy directly targets the mechanisms that sustain lung injury after exposure. We recently showed that oxidative mitochondrial DNA (mtDNA) damage drives chlorine-induced lung injury and that post-exposure delivery of a fusion protein containing mitochondria-targeted 8-oxoguanine DNA glycosylase-1 (mOGG1) mitigates lung injury and improves survival. However, the cell populations and transcriptional states through which mtDNA injury shapes lung damage and repair remain unclear. Here, we used single-nucleus RNA sequencing to define early cellular ","pubDate":"2026-10-21","url":"https://www.biorxiv.org/content/10.64898/2026.10.20.760415v1?rss=1"},"indexado":"2026-10-21T16:39:55.345Z"}}