{"ok":true,"nota":{"id":"6956518b41e0b1bd","slug":"quienes-tienen-problemas-cardiovasculares-renales-y-metabolicos-juntos-695651","titulo":"Quienes tienen problemas cardiovasculares, renales y metabólicos juntos muestran más deterioro cognitivo con l","resumen":"Analizaron cohortes de adultos mayores de varios países durante varios años para ver cómo se relaciona el síndrome cardiovascular-renal-metabólico con la memoria, la depresión y cambios en imágenes cerebrales. Clasificaron a los participantes por etapas, de 0 a 4.","fuente":"medrxiv","fuenteNombre":"medRxiv · preprints","color":"#1f7a4d","autor":"Zhang, H., Liao, Y., Zhang, w., Lin, Z., Lipnicki, D., Ji, H., Yan, Y., Zhang, Y., Brodaty, H., Wen, W., Kochan, N., Num","url":"https://www.medrxiv.org/content/10.64898/2026.10.21.26366180v1?rss=1","imagen":"/hoy/portada/6956518b41e0b1bd","tema":"salud","subtemas":["deterioro cognitivo","salud cardiovascular","enfermedad renal","depresion en adultos mayores","envejecimiento"],"entidades":["síndrome cardiovascular-renal-metabólico","cohortes de envejecimiento global","Cohort Studies of Memory in an International Consortium"],"formato":"dato","entretenimiento":false,"pubTs":"2026-10-27T00:00:00.000Z","indexTs":"2026-10-27T20:35:58.383Z","hash":"94b7e85c3801da8adec1bcd42e04f77dd566168b57378d957d705c0dc73c3663","tsa":{"time":"Oct 27 20:37:12 2026 GMT","provider":"freetsa.org","sobre":"sello"},"stats":{"views":1,"likes":0,"clicks":0,"dwell":0},"tipo":"normal","registro":"hallazgo","porQueImporta":"Cuanto más avanzan a la vez el corazón, los riñones y el metabolismo, más se asocian con pérdida de memoria y síntomas depresivos en personas mayores. Eso confirma que la salud del cuerpo y la del cerebro no se separan, y que el deterioro cognitivo no es solo cuestión de la edad. Para una persona de cuarenta o cincuenta años, controlar presión, azúcar y función renal hoy es una forma concreta de cuidar la memoria mañana. El estudio es observacional, así que muestra asociación y no prueba que una cosa cause la otra.","quienFirma":"medRxiv (preprint; institución de los autores no especificada en la fuente)","confianza":"preprint","consulta":null},"sello":{"hash":"94b7e85c3801da8adec1bcd42e04f77dd566168b57378d957d705c0dc73c3663","sello":"eb69417741463fd9438aac4bc5cab6d336af63dbf3518a55817f2de80947606e","beacon":{"drand":{"cadena":"8990e7a9aaed2ffed73dbd7092123d6f289930540d7651336225dc172e51b2ce","ronda":6590080,"aleatorio":"1ac2a3d48db0c0c1db83b25f4cf59190cd0c4df99e61833be63055423f92b5d1","tiempo":"2026-10-27T20:37:00.000Z"},"nist":null,"noAntes":"2026-10-27T20:37:00.000Z"},"verificacion":{"drand":true,"nist":null},"tsa":{"time":"Oct 27 20:37:12 2026 GMT","provider":"freetsa.org","sobre":"sello"},"original":{"titulo":"Stage-dependent associations of Cardiovascular-Kidney-Metabolic Syndrome with Cognitive Decline, Depression, and Neuroimaging Signatures in multi-regional older adults","descripcion":"Background Cardiovascular-Kidney-Metabolic (CKM) syndrome is a multisystem condition associated with adverse outcomes, yet its impact on age-related cognitive health remains understudied. We examined associations of CKM with neurocognitive and neuropsychiatric outcomes, modifiable physical and psychosocial factors contributing to cognitive impairment across CKM stages, and neuroimaging correlates. Methods Global aging cohorts (mean follow-up 6.5 years) and the Cohort Studies of Memory in an International Consortium (5.4 years) were used. CKM stages (0-4) were defined according to AHA framework. Longitudinal domain-specific cognitive changes were assessed using linear mixed-effects models, an","pubDate":"2026-10-27","url":"https://www.medrxiv.org/content/10.64898/2026.10.21.26366180v1?rss=1"},"indexado":"2026-10-27T20:35:58.383Z"}}